Science | Nature | Cell | View More
Natural Products
Mangostanol
Mangostanol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Mangostanol
Price:
CAS No.: 184587-72-2
Catalog No.: CFN99856
Molecular Formula: C24H26O7
Molecular Weight: 426.5 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Indian Institute of Science (India)
  • Biotech R&D Institute (USA)
  • Sapienza University of Rome (Italy)
  • Mahatma Gandhi University (India)
  • Instituto de Investigaciones Ag... (Chile)
  • Universidade Federal de Pernamb... (Brazil)
  • Georgia Institute of Technology (USA)
  • Medical University of South Car... (USA)
  • Korea Food Research Institute(K... (Korea)
  • University of Bordeaux (France)
  • Kyung Hee University (Korea)
  • More...
Package
Featured Products
Ganoderiol F

Catalog No: CFN99244
CAS No: 114567-47-4
Price: $398/5mg
Curzerenone

Catalog No: CFN92027
CAS No: 20493-56-5
Price: $358/20mg
Chikusetsusaponin IVa

Catalog No: CFN92516
CAS No: 51415-02-2
Price: $80/20mg
1-Dehydro-10-gingerdione

Catalog No: CFN92374
CAS No: 136826-50-1
Price: $ / mg
Pallidol

Catalog No: CFN92341
CAS No: 105037-88-5
Price: $318/10mg
Kaempferol 3-gentiobioside

Catalog No: CFN92384
CAS No: 22149-35-5
Price: $80/20mg
beta-Eudesmol

Catalog No: CFN99537
CAS No: 473-15-4
Price: $288/20mg
Neoschaftoside

Catalog No: CFN92071
CAS No: 61328-41-4
Price: $368/10mg
Echinacoside

Catalog No: CFN98105
CAS No: 82854-37-3
Price: $30/20mg
Lithospermic acid

Catalog No: CFN98546
CAS No: 28831-65-4
Price: $138/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 values of 9.6 microg/ml.
Targets: AChR
In vitro:
J Asian Nat Prod Res. 2008 May-Jun;10(5-6):475-9.
Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.[Pubmed: 18464091]
Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds.
METHODS AND RESULTS:
The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone. Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), garcinone D (5), Mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), Mangostanol (6), and garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2 microg/ml, respectively.
CONCLUSIONS:
This is the first report on the cytotoxicity of the extracts of the stem and root bark of G. mangostana and of alpha-mangostin, Mangostanol, and garcinone D against the CEM-SS cell line.
Mangostanol Description
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Leachianol F

Catalog No: CFN95147
CAS No: 164123-50-6
Price: $318/5mg
Methylgomisin O

Catalog No: CFN95236
CAS No: 1276654-07-9
Price: $318/5mg
cis-Aegineoside

Catalog No: CFN95295
CAS No: N/A
Price: $413/5mg
Arjungenin

Catalog No: CFN95039
CAS No: 58880-25-4
Price: $318/20mg
Mahuannin J

Catalog No: CFN95533
CAS No: N/A
Price: $318/5mg
Arisantetralone B

Catalog No: CFN95211
CAS No: 1161947-96-1
Price: $413/5mg
Symplocoside

Catalog No: CFN95552
CAS No: 76502-76-6
Price: $318/5mg
3-Hydroxymollugin

Catalog No: CFN95424
CAS No: 154706-45-3
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3447 mL 11.7233 mL 23.4467 mL 46.8933 mL 58.6166 mL
5 mM 0.4689 mL 2.3447 mL 4.6893 mL 9.3787 mL 11.7233 mL
10 mM 0.2345 mL 1.1723 mL 2.3447 mL 4.6893 mL 5.8617 mL
50 mM 0.0469 mL 0.2345 mL 0.4689 mL 0.9379 mL 1.1723 mL
100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.4689 mL 0.5862 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Phytomedicine. 2014 Sep 25;21(11):1303-9.
Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies.[Pubmed: 25172794]

METHODS AND RESULTS:
Among the xanthones, Mangostanol, 3-isomangostin, garcinone C and α-mangostin are AChE selective inhibitors, 8-deoxygartanin is a BChE selective inhibitor while γ-mangostin is a dual inhibitor. Preliminary structure-activity relationship suggests the importance of the C-8 prenyl and C-7 hydroxy groups for good AChE and BChE inhibitory activities. The enzyme kinetic studies indicate that both α-mangostin and garcinone C are mixed-mode inhibitors, while γ-mangostin is a non-competitive inhibitor of AChE. In contrast, both γ-mangostin and garcinone C are uncompetitive inhibitors, while α-mangostin is a mixed-mode inhibitor of BChE.
CONCLUSIONS:
Molecular docking studies revealed that α-mangostin, γ-mangostin and garcinone C interacts differently with the five important regions of AChE and BChE. The nature of protein-ligand interactions is mainly hydrophobic and hydrogen bonding. These bioactive prenylated xanthones are worthy for further investigations
Ganoderiol F

Catalog No: CFN99244
CAS No: 114567-47-4
Price: $398/5mg
Curzerenone

Catalog No: CFN92027
CAS No: 20493-56-5
Price: $358/20mg
Chikusetsusaponin IVa

Catalog No: CFN92516
CAS No: 51415-02-2
Price: $80/20mg
1-Dehydro-10-gingerdione

Catalog No: CFN92374
CAS No: 136826-50-1
Price: $ / mg
Pallidol

Catalog No: CFN92341
CAS No: 105037-88-5
Price: $318/10mg
Kaempferol 3-gentiobioside

Catalog No: CFN92384
CAS No: 22149-35-5
Price: $80/20mg
beta-Eudesmol

Catalog No: CFN99537
CAS No: 473-15-4
Price: $288/20mg
Neoschaftoside

Catalog No: CFN92071
CAS No: 61328-41-4
Price: $368/10mg
Echinacoside

Catalog No: CFN98105
CAS No: 82854-37-3
Price: $30/20mg
Lithospermic acid

Catalog No: CFN98546
CAS No: 28831-65-4
Price: $138/20mg
Tags: buy Mangostanol | Mangostanol supplier | purchase Mangostanol | Mangostanol cost | Mangostanol manufacturer | order Mangostanol | Mangostanol distributor