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(+)-Mellein
(+)-Mellein
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name (+)-Mellein
Price:
CAS No.: 62623-84-1
Catalog No.: CFN96915
Molecular Formula: C10H10O3
Molecular Weight: 178.18 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The leaves and stems of Stevia lucida Lagasca.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: (+)-Mellein is a natural product from Stevia lucida Lagasca.
(+)-Mellein Description
Source: The leaves and stems of Stevia lucida Lagasca.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.6123 mL 28.0615 mL 56.123 mL 112.246 mL 140.3076 mL
5 mM 1.1225 mL 5.6123 mL 11.2246 mL 22.4492 mL 28.0615 mL
10 mM 0.5612 mL 2.8062 mL 5.6123 mL 11.2246 mL 14.0308 mL
50 mM 0.1122 mL 0.5612 mL 1.1225 mL 2.2449 mL 2.8062 mL
100 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1225 mL 1.4031 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Avances En Química, 2013,8(3):145-151.
Isolation and characterization of (+)-mellein, the first isocoumarin reported in Stevia genus[Reference: WebLink]

METHODS AND RESULTS:
From the acetone extract obtained of leaves and stems of Stevia lucida Lagasca were isolated the following phenolic derivatives: (+)-Mellein [1], hispidulin [2], pectolinaringenin [3] and isosakuranetin [4]. These compounds were characterized on the basis of spectroscopic studies, including 1D- and 2D-NMR experiments.
CONCLUSIONS:
The literature review indicated that isocoumarins are rather rare compounds in higher plants. This gives importance to their discovery in the Stevia genus.
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p-Hydroxy-cinnamic acid

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(+)-Sophoranol

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