| In vitro: |
| International Symposium on Information Technology in Medicine and Education. IEEE, 2012:1000-1003. | | Identification of gallicin from Myricaria laxiflora and its antibiotic & antioxidant activity[Reference: WebLink] | Myricaria Laxiflora is a rare and endangered riparian shrub in Three Gorges zone, China. Locally, the plants are widely used as a traditional herbal medicine for scald and arthritis, but the pharmacological activity has not been elucidated, and the mechanism was far from clear. In order to explore the possible pharmacological mechanism, 6 compounds were extracted here by chloroform in the 95% ethanol precipitation under different pH value.
METHODS AND RESULTS:
After investigation of the antimicrobial activity in vitro through eight microorganisms, we found the compounds in different pH condition showed specific inhibitory activity to bacteria and fungus. In pH=7 extract, we isolated a gallic acid derivant named Methyl 3-hydroxy-4,5-dimethoxybenzoate (gallicin) by 1D, 2D NMR and MS identification, and this compound showed obvious antimicrobial activities.
CONCLUSIONS:
The minimum inhibitory concentration of this compound was 5 mg/ml against Staphylococcus aureus and Rhizopus, and 10 mg/ml against E. coli. Furthermore, just like propyl gallate, gallicin showed fairly active for oxidation resistance in the presence of H2O2. |
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