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Mogroside IVe
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Mogroside IVe
Price: $288 / 10mg
CAS No.: 88915-64-4
Catalog No.: CFN92189
Molecular Formula: C54H92O24
Molecular Weight: 1125.3 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The fruits of Siraitia grosvenorii Swingle.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $227.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
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  • University of Lodz (Poland)
  • University of the Basque Country (Spain)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Mogroside IVe can inhibit the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice in a dose-dependent manner, which is accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2.
Targets: p53 | ERK | MMP(e.g.TIMP)
In vitro:
Nutrients, 2016, 8(6):360.
Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer[Pubmed: PMC4924201]
Colorectal cancer and throat cancer are the world’s most prevalent neoplastic diseases, and a serious threat to human health. Plant triterpene glycosides have demonstrated antitumor activity.
METHODS AND RESULTS:
In this study, we investigated potential anticancer effects of Mogroside IVe, a triterpenoid glycoside from monk fruit, using in vitro and in vivo models of colorectal and laryngeal cancer. The effects of Mogroside IVe on the proliferation of colorectal cancer HT29 cells and throat cancer Hep-2 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the expression levels of p53, phosphorylated ERK1/2, and MMP-9 were analyzed by western blotting and immunohistochemistry. The results indicated that Mogroside IVe inhibited, in a dose-dependent manner, the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice, which was accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2.
CONCLUSIONS:
This study revealed the suppressive activity of Mogroside IVe towards colorectal and throat cancers and identified the underlying mechanisms, suggesting that Mogroside IVe may be potentially used as a biologically-active phytochemical supplement for treating colorectal and throat cancers.
Mogroside IVe Description
Source: The fruits of Siraitia grosvenorii Swingle.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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IF=13.297(2019)

PMID: 28005066

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.8887 mL 4.4433 mL 8.8865 mL 17.773 mL 22.2163 mL
5 mM 0.1777 mL 0.8887 mL 1.7773 mL 3.5546 mL 4.4433 mL
10 mM 0.0889 mL 0.4443 mL 0.8887 mL 1.7773 mL 2.2216 mL
50 mM 0.0178 mL 0.0889 mL 0.1777 mL 0.3555 mL 0.4443 mL
100 mM 0.0089 mL 0.0444 mL 0.0889 mL 0.1777 mL 0.2222 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Geissoschizine methyl ether

Catalog No: CFN89459
CAS No: 60314-89-8
Price: $268/10mg
Poncirin

Catalog No: CFN90448
CAS No: 14941-08-3
Price: $168/20mg
Lasiocarpine

Catalog No: CFN00289
CAS No: 303-34-4
Price: $ /
6beta-Hydroxystigmast-4-en-3-one

Catalog No: CFN98496
CAS No: 36450-02-9
Price: $ /
4-Hydroxybenzoic acid

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CAS No: 99-96-7
Price: $30/20mg
1-O-Acetylbritannilactone

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Scopolamine

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beta-Eudesmol

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Tectorigenin

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