Myriceric acid B | CAS:55497-79-5 | Manufacturer ChemFaces

Myriceric acid B

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Description:

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 value of 6.8 uM, it also exhibits cytotoxic activity towards the MOLT-3 cell line with IC50 values of 3.9 uM.

Targets:

HIV

In vitro:

Eur. J.Org. Chem. 2011, 2011(20-21): 3809-14.

Protoberberine Alkaloids and Cancer Chemopreventive Properties of Compounds from Alangium salviifolium[Reference: WebLink]

METHODS AND RESULTS:
New protoberberine alkaloids, namely alangiumkaloids A (1) and B (2), 27-O-trans-caffeoylcylicodiscic acid (3), and β-d-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (5) together with Myriceric acid B (4), isoalangiside (6), alangiside (7), 3-O-demethyl-2-O-methylalangiside (8), and demethylalangiside (9) have been isolated from Alangium salviifolium. The cancer chemopreventive properties and cytotoxic activities of the isolated compounds were evaluated.
CONCLUSIONS:
Compounds Myriceric acid B, 4, and 9 scavenged DPPH free radicals with IC50 values of 21.4, 21.8, and 24.0 μm, respectively. Alangisides 7 and 9 inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay with IC50 values of 19.4 and 5.3 μm, respectively. Compounds 6–9 showed excellent antioxidant activity in the oxygen radical absorbance capacity (ORAC) assay with 12.8–24.9 ORAC units. Compounds 3 and Myriceric acid B inhibited aromatase activity with IC50 values of 4.7 and 6.8 μm, respectively. Although the isolated compounds showed only weak cytotoxicity or were inactive, compounds 3 and Myriceric acid B exhibited cytotoxic activity towards the MOLT-3 cell line with IC50 values of 5.6 and 3.9 μm, respectively.

Myriceric acid B Description

Source:	The root barks of Myrica cerifera L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Chinese Pharmacological Bulletin, 2010, 26(4):447-451+452.

The anti-HIV-1 entrance activity and mechanism of action of myriceric acid B from Rhoiptelea chiliantha Diels et Hand-Mazz.[Reference: WebLink]

To investigate the HIV-1 entry inhibitory activities of Myriceric acid B and C isolated from Rhoiptelea chiliantha Diels et Hand-Mazz and their mechanism of action.
METHODS AND RESULTS:
The plasmids encoding envelope proteins of HIV-1 (pHXB2) and VSV (pVSV-G) were cotransfected 293T cells with pNL4-3. Luc. R-E- to produce HIV-1 Env pseudovirus and VSV-G pseudovirus, respectively, which were used for testing the antiviral activities of these compounds. ELISA and molecular docking were used to study the mechanism of action of the active compounds. Myriceric acid B could significantly inhibit the infection of HIV-1 Env pseudovirus with an IC50 of (8.3 ± 0.2) mg·L-1. The carbonoxyl group at C-28 position and the hydroxyl group at the C-3 position of Myriceric acid B are important for its anti-HIV-1 activity. Like other HIV-1 entry inhibitors targeting gp41 (eg, ADS-J1 and NB-64), Myriceric acid B could also block the gp41 six-helix bundle formation. Molecular docking analysis suggests that Myriceric acid B may bind to the hydrophobic cavity of the gp41 N-trimeric coiled coil.
CONCLUSIONS:
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug.

Product Name	Myriceric acid B
Price:
CAS No.:	55497-79-5
Catalog No.:	CFN98931
Molecular Formula:	C₃₉H₅₄O₇
Molecular Weight:	634.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The root barks of Myrica cerifera L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antioxidants Compound Library Antiviral Compound Library Cytotoxic Compound Library Triterpenoids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5751 mL	7.8753 mL	15.7505 mL	31.501 mL	39.3763 mL
5 mM	0.315 mL	1.5751 mL	3.1501 mL	6.3002 mL	7.8753 mL
10 mM	0.1575 mL	0.7875 mL	1.5751 mL	3.1501 mL	3.9376 mL
50 mM	0.0315 mL	0.1575 mL	0.315 mL	0.63 mL	0.7875 mL
100 mM	0.0158 mL	0.0788 mL	0.1575 mL	0.315 mL	0.3938 mL

CFN91471	Hederagenin methyl ester	17736-04-8	486.7	C₃₁H₅₀O₄
CFN92845	(Z)-23-Coumaroylhederagenin	654678-61-2	618.4	C₃₉H₅₄O₆
CFN98696	Hederagonic acid	466-01-3	470.7	C₃₀H₄₆O₄
CFN99636	Uncargenin C	152243-70-4	488.7	C₃₀H₄₈O₅
CFN98227	3-Hydroxy-12-oleanene-23,28-dioic acid	226562-47-6	486.7	C₃₀H₄₆O₅
CFN96468	Uncarinic acid E	277751-61-8	618.84	C₃₉H₅₄O₆
CFN98931	Myriceric acid B	55497-79-5	634.9	C₃₉H₅₄O₇
CFN99683	Myriceric acid C	162059-94-1	797.0	C₄₈H₆₀O₁₀
CFN91480	Sumaresinolic acid	559-64-8	472.7	C₃₀H₄₈O₄
CFN99802	Wilforol C	168254-95-3	472.7	C₃₀H₄₈O₄