Myrislignan | CAS:171485-39-5 | Manufacturer ChemFaces

Myrislignan

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Myrislignan
Price:	$198 / 20mg
CAS No.:	171485-39-5
Catalog No.:	CFN99752
Molecular Formula:	C₂₁H₂₆O₆
Molecular Weight:	374.43 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	White powder
Source:	The seeds of Myristica fragrans Houtt.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $63.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induced apoptosis and cell cycle arrest in A549 cells.

Targets:

NO | TNF-α | NOS | COX | NF-kB | IkB | Bcl-2/Bax | c-Myc | IKK

In vitro:

J Nat Med. 2017 Jan;71(1):76-85.

The action and mechanism of myrislignan on A549 cells in vitro and in vivo.[Pubmed: 27491743 ]

Myrislignan is a natural compound with little pharmacological study. In our investigation, we investigated the effect of Myrislignan in the induction of apoptosis in A549 cells in vitro and in vivo.
METHODS AND RESULTS:
Myrislignan inhibited the proliferation of A549 cells in a dose- and time-dependent manner assayed by MTT. In addition, Hoechst flow cytometry showed that Myrislignan significantly induced apoptosis and cell cycle arrest in A549 cells. The apoptosis and anti-cell proliferation was mediated by the activation of mitogen-activated protein kinase and the inhibition of epidermal growth factor receptor signal pathway, change of mitochondrial membrane potential, the releasing of c-Myc, the downregulation of the level of the anti-apoptotic protein Bcl-2, and the upregulation of the level of the pro-apoptotic protein Bax.
CONCLUSIONS:
In conclusion, those results reveal a potential mechanism for the anti-cancer effect of Myrislignan on human lung cancer, while suggesting that Myrislignan may be a promising compound for the treatment of lung cancer.

Myrislignan Description

Source:	The seeds of Myristica fragrans Houtt.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Food Chem. 2015 Apr 15;173:231-7.

New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production.[Pubmed: 25466017]

Five new 8-O-4' type neolignans, named myrifralignan A-E (1-5), together with five known analogues (6-10), were isolated from the seeds of Myristica fragrans Houtt.
METHODS AND RESULTS:
Their chemical structures were determined using several spectroscopic methods. Compounds 3-10 exhibited potent inhibitory activity against the production of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. Myrislignan (7) and machilin D (10) were the most potent inhibitors of NO production amongst these compounds. The IC50 values of Myrislignan and machilin D were 21.2 and 18.5 μM. And, their inhibitory activity was more than L-N(6)-(1-iminoethyl)-lysine, a selective inhibitor of inducible nitric oxide synthase (IC50=27.1 μM). Furthermore, real-time PCR analysis revealed that these neolignans could significantly suppress the expression of inducible nitric oxide synthase mRNA.
CONCLUSIONS:
These results demonstrated that the 8-O-4' type neolignans are promising candidates as anti-inflammatory agents.

Cell Research:

Phytother Res. 2012 Sep;26(9):1320-6.

Myrislignan attenuates lipopolysaccharide-induced inflammation reaction in murine macrophage cells through inhibition of NF-κB signalling pathway activation.[Pubmed: 22294521]

Myrislignan is a new kind of lignan isolated from Myristica fragrans Houtt. Its antiinflammatory effects have not yet been reported.
METHODS AND RESULTS:
In the present study, the antiinflammatory effects and the underlying mechanisms of Myrislignan in lipopolysaccharide (LPS)-induced inflammation in murine RAW 264.7 macrophage cells were investigated. Myrislignan significantly inhibited LPS-induced production of nitric oxide (NO) in a dose-dependent manner. It inhibited mRNA expression and release of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). This compound significantly inhibited mRNA and protein expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Further study showed that Myrislignan decreased the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and the translocation of NF-κB from cytoplasm to the nucleus.
CONCLUSIONS:
Our results suggest that Myrislignan may exert its antiinflammatory effects in LPS-stimulated macrophages cells by inhibiting the NF-κB signalling pathway activation.

Structure Identification:

Biomed Chromatogr. 2008 Jun;22(6):601-5.

Quantification of myrislignan in rat plasma by solid-phase extraction and reversed-phase high-performance liquid chromatography.[Pubmed: 18254153]

METHODS AND RESULTS:
A rapid and simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for determination of Myrislignan in rat plasma after intravenous administration. The analytes extracted from plasma samples by solid-phase extraction were successfully carried out on a Diamonsiltrade mark ODS C(18) column (250 x 4.6 mm i.d., 5 microm) with an RP(18) guard column (8 x 4.6 mm i.d., 5 microm) and a mobile phase of MeOH-H(2)O (4:1, v/v). The UV detector was set at a single wavelength of 270 nm. The linear ranges of the standard curves were 0.5-30.0 microg/mL with the correlation coefficients greater than 0.9992. The lower limits of detection and quantification were 0.1 and 0.3 microg/mL for Myrislignan. Intra- and inter-day precisions were 2.4-7.5 and 1.3-5.7%, respectively. The extraction recovery from plasma was more than 90%.
CONCLUSIONS:
This assay method has been successfully used to study the pharmacokinetics of Myrislignan in rats.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Phenylpropanoids Compound Library TNF-α Inhibitor Library NOS Inhibitor Library NO Inhibitor Library NF-kB Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library COX Inhibitor Library c-Myc Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6707 mL	13.3536 mL	26.7073 mL	53.4145 mL	66.7682 mL
5 mM	0.5341 mL	2.6707 mL	5.3415 mL	10.6829 mL	13.3536 mL
10 mM	0.2671 mL	1.3354 mL	2.6707 mL	5.3415 mL	6.6768 mL
50 mM	0.0534 mL	0.2671 mL	0.5341 mL	1.0683 mL	1.3354 mL
100 mM	0.0267 mL	0.1335 mL	0.2671 mL	0.5341 mL	0.6677 mL

CFN97457	erythro-Guaiacylglycerol beta-coniferyl ether	890317-92-7	376.4	C₂₀H₂₄O₇
CFN97431	threo-Guaiacylglycerol beta-coniferyl ether	869799-76-8	376.4	C₂₀H₂₄O₇
CFN95756	New compound 36	N/A	362.4	C₁₉H₂₂O₇
CFN96620	threo-7-O-Methylguaiacylglycerol beta-coniferyl ether	150333-85-0	390.43	C₂₁H₂₆O₇
CFN95416	Erythro-Guaiacylglycerol-beta-coniferyl aldehyde ether	74474-55-8	374.4	C₂₀H₂₂O₇
CFN95417	threo-Guaiacylglycerol-beta-coniferyl aldehyde ether	650600-33-2	374.4	C₂₀H₂₂O₇
CFN95625	alpha-[4-[(1E)-2-Carboxyethenyl]-2-hydroxyphenoxy]-beta,3,4-trihydroxybenzenepropanoic acid	285136-03-0	376.3	C₁₈H₁₆O₉
CFN89049	erythro-Guaiacylglycerol beta-sinapyl ether 7-O-glucoside	412029-03-9	568.57	C₂₇H₃₆O₁₃
CFN95178	Citrusin B	105279-10-5	568.6	C₂₇H₃₆O₁₃
CFN96310	erythro-Guaiacylglycerol beta-sinapyl ether	877875-96-2	406.4	C₂₁H₂₆O₈