N-(3-Methoxybenzyl)palmitamide | CAS:847361-96-0

N-(3-Methoxybenzyl)palmitamide

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Description:

N-(3-methoxybenzyl)palmitamide is a promising inhibitor of fatty acid amide hydrolase (FAAH) and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders. N-(3-Methoxybenzyl)palmitamide can counteract the toxicity produced by Aβ (25-35).

Targets:

Beta Amyloid | Caspase

In vitro:

Life Sciences, 1992 , 51 (10) :779-86.

Neuroprotective effects of Lepidium meyenii (Maca) and macamides against amyloid-beta (25-35) induced toxicity in B-35 neuroblastoma cells (657.13)[Reference: WebLink]

The purpose of this study was to evaluate the neuroprotective effects of a Maca pentane extract (5-50 μg/mL) and some of the component macamides: N-benzylpalmitamide, N-benzyloleamide and N-(3-Methoxybenzyl)palmitamide (1-30 μM) on the B-35 neuroblastoma cell line.
METHODS AND RESULTS:
B-35 cells were pre-treated with extract or macamides and subsequently exposed to a neurotoxic concentration (10 μM) of Aβ (25-35). A cell viability assay utilizing 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) was performed to evaluate the neuroprotective effects. The results demonstrated that the Maca extract and N-(3-Methoxybenzyl)palmitamide counteracted the toxicity produced by Aβ (25-35), demonstrating significant increases in cell viability (34% and 21% respectively). Furthermore, when the tested compounds were evaluated for antioxidant activity and their effects on caspase 3, neither the Maca extract nor N-(3-Methoxybenzyl)palmitamide demonstrated an antioxidant effect or caspase 3 inhibition.
CONCLUSIONS:
These results suggest that the Maca extract and macamides may produce neuroprotective effects against Aβ by mechanisms other than caspase 3 inhibition or an antioxidant effect.

N-(3-Methoxybenzyl)palmitamide Description

Source:	The herbs of Lepidium meyenii Walp
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Le Chirurgien-dentiste de France , 1984 , 53 (228) :33-6.

Inhibitory effect of macamides: N-benzylpalmitamide and N-(3-methoxybenzyl)palmitamide on fatty acid amide hydrolase (FAAH)[Reference: WebLink]

METHODS AND RESULTS:
Each compound was tested at concentrations from 1 to 100 μM, using an FAAH inhibitory activity assay, which is a fluorescence-based method. The results demonstrated that each of the test compounds causes a concentration-dependent inhibition of FAAH. The pre-incubation study revealed that N-benzylpalmitamide and N-(3-Methoxybenzyl)palmitamide inhibit FAAH in a time-dependent manner. The % inhibition of FAAH produced by 100 μM N-(3-Methoxybenzyl)palmitamide without pre-incubation was comparable to that of N-benzylpalmitamide. However, a 120 min pre-incubation of inhibitor with FAAH caused a significant increase in the % inhibition produced by 100 μM N-(3-Methoxybenzyl)palmitamide. The enzyme kinetics study indicated that N-(3-Methoxybenzyl)palmitamide is likely an uncompetitive inhibitor of FAAH. LC-MS/MS analysis determined that N-(3-Methoxybenzyl)palmitamide is a substrate of FAAH since it undergoes hydrolysis by FAAH.
METHODS AND RESULTS:
The results of this study indicated that N-(3-Methoxybenzyl)palmitamide is a promising inhibitor of FAAH and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders.

Product Name	N-(3-Methoxybenzyl)palmitamide
Price:	$198 / 20mg
CAS No.:	847361-96-0
Catalog No.:	CFN90846
Molecular Formula:	C₂₄H₄₁NO₂
Molecular Weight:	375.6 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Lepidium meyenii Walp
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Neuroprotection Compound Library Alkaloids Compound Library Caspase Inhibitor Library Beta Amyloid Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6624 mL	13.312 mL	26.6241 mL	53.2481 mL	66.5602 mL
5 mM	0.5325 mL	2.6624 mL	5.3248 mL	10.6496 mL	13.312 mL
10 mM	0.2662 mL	1.3312 mL	2.6624 mL	5.3248 mL	6.656 mL
50 mM	0.0532 mL	0.2662 mL	0.5325 mL	1.065 mL	1.3312 mL
100 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.5325 mL	0.6656 mL

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CFN99529	Leonurine hydrochloride	24735-18-0	347.8	C₁₄H₂₁O₅N₃.HCl
CFN97210	Odorine	72755-20-5	300.4	C₁₈H₂₄N₂O₂
CFN97211	Odorinol	72755-22-7	316.4	C₁₈H₂₄N₂O₃
CFN90843	Macamide B	74058-71-2	345.6	C₂₃H₃₉NO
CFN90844	N-Benzyloleamide	883715-21-7	371.6	C₂₅H₄₁NO
CFN90842	(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide	18286-71-0	369.6	C₂₅H₃₉NO
CFN90866	N-Benzyllinolenamide	883715-18-2	367.6	C₂₅H₃₇NO
CFN90846	N-(3-Methoxybenzyl)palmitamide	847361-96-0	375.6	C₂₄H₄₁NO₂
CFN90847	N-(3-Methoxybenzyl)oleamide	883715-21-7	401.6	C₂₆H₄₃NO₂