NG,NG-Dimethylarginine dihydrochloride | CAS:220805-22-1

NG,NG-Dimethylarginine dihydrochloride

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Description:

NG,NG-Dimethylarginine dihydrochloride is a reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Targets:

In vivo:

Lancet. 1992 Mar 7;339(8793):572-5.

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.[Pubmed: 1347093]

Nitric oxide (NO), synthesised from L-arginine, contributes to the regulation of blood pressure and to host defence.
METHODS AND RESULTS:
We describe in-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine (asymmetrical dimethylarginine, ADMA). In man, this inhibitor is found in plasma and more than 10 mg is excreted in urine over 24 h. However, in patients with end-stage chronic renal failure, who have little or no urine output, elimination is blocked and circulating concentrations of the inhibitor rise sufficiently to inhibit NO synthesis.
CONCLUSIONS:
Accumulation of endogenous ADMA, leading to impaired NO synthesis, might contribute to the hypertension and immune dysfunction associated with chronic renal failure.

NG,NG-Dimethylarginine dihydrochloride Description

Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	NG,NG-Dimethylarginine dihydrochloride
Price:
CAS No.:	220805-22-1
Catalog No.:	CFN90056
Molecular Formula:	C₈H₂₀Cl₂N₄O₂
Molecular Weight:	275.18 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.634 mL	18.1699 mL	36.3399 mL	72.6797 mL	90.8496 mL
5 mM	0.7268 mL	3.634 mL	7.268 mL	14.5359 mL	18.1699 mL
10 mM	0.3634 mL	1.817 mL	3.634 mL	7.268 mL	9.085 mL
50 mM	0.0727 mL	0.3634 mL	0.7268 mL	1.4536 mL	1.817 mL
100 mM	0.0363 mL	0.1817 mL	0.3634 mL	0.7268 mL	0.9085 mL

CFN90028	4-Aminobutanoic acid	56-12-2	103.12	C₄H₉NO₂
CFN90013	Pregabalin	148553-50-8	159.23	C₈H₁₇NO₂
CFN90214	L-4-Hydroxyisoleucine	6001-78-8	147.17	C₆H₁₃NO₃
CFN99739	L-Carnitine inner salt	541-15-1	161.20	C₇H₁₅NO₃
CFN90064	Tetraethoxypropane	122-31-6	220.31	C₁₁H₂₄O₄
CFN98511	Tricine	5704-04-1	179.17	C₆H₁₃NO₅
CFN90413	Dencichin	7554-90-7	176.13	C₅H₈N₂O₅
CFN90056	NG,NG-Dimethylarginine dihydrochloride	220805-22-1	275.18	C₈H₂₀Cl₂N₄O₂