Nemoralisin C | CAS:1443421-84-8 | Manufacturer ChemFaces

Nemoralisin C

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Description:

Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.

In vitro:

Chem Pharm Bull (Tokyo). 2014;62(5):494-8.

Aphanamixins A-F, acyclic diterpenoids from the stem bark of Aphanamixis polystachya.[Pubmed: 24789934]

METHODS AND RESULTS:
Six new acyclic diterpenoids named Aphanamixins A-F (1-6), together with two known compounds of nemoralisin and Nemoralisin C, were isolated from the stem bark of Aphanamixis polystachya (WALL) J. N. BARKER. Their structures were established through a comprehensive analysis of NMR spectroscopic data and high resolution mass spectrometric data. The absolute configurations of carbon stereocenters were determined by means of auxiliary chiral α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) derivatives and circular dichroism (CD), respectively.
CONCLUSIONS:
All the new isolates were tested for their antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines and they exhibited weak cytotoxicities (IC50>10 μM). Moreover, we highlighted that the six new diterpenoids characterized by acyclic skeleton was rarely seen in nature.

Nemoralisin C Description

Source:	The stem-barks of Aphanamixis polystachya.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Nemoralisin C
Price:
CAS No.:	1443421-84-8
Catalog No.:	CFN89403
Molecular Formula:	C₂₀H₂₈O₅
Molecular Weight:	348.43 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The stem-barks of Aphanamixis polystachya.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.87 mL	14.3501 mL	28.7002 mL	57.4003 mL	71.7504 mL
5 mM	0.574 mL	2.87 mL	5.74 mL	11.4801 mL	14.3501 mL
10 mM	0.287 mL	1.435 mL	2.87 mL	5.74 mL	7.175 mL
50 mM	0.0574 mL	0.287 mL	0.574 mL	1.148 mL	1.435 mL
100 mM	0.0287 mL	0.1435 mL	0.287 mL	0.574 mL	0.7175 mL

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CFN92053	Ganoderic acid C1	95311-97-0	514.7	C₃₀H₄₂O₇
CFN96045	Pedalitin	22384-63-0	316.3	C₁₆H₁₂O₇
CFN98803	14,15-Didehydroisoeburnamine	50838-11-4	294.4	C₁₉H₂₂N₂O