Osthenone | CAS:112789-90-9 | Manufacturer ChemFaces

Osthenone

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Description:

Osthenone shows strong activity against the cancer cell lines, whereas it has weak antiproliferative activity against the normal human cell lines.

In vitro:

Anticancer Res. 2001 May-Jun;21(3B):1905-11.

Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.[Pubmed: 11497276]

METHODS AND RESULTS:
33 coumarins, mainly the simple isopentenylated coumarins and derived pyrano- and furanocoumarins, were examined for their antiproliferative activity towards several cancer and normal human cell lines. The pyrano- and furanocoumarins showed strong activity against the cancer cell lines, whereas they had weak antiproliferative activity against the normal human cell lines. The decreasing rank order of potency was Osthenone (10), clausarin (25), clausenidin (26), dentatin (24), nordentatin (23), imperatorin (29), seselin (27), xanthyletin (21), suberosin (17), phebalosin (8) and osthol (12).
CONCLUSIONS:
The structure-activity relationship established from the results revealed that the 1,1-dimethylallyl and isopentenyl groups have an important role for antiproliferative activity.

Osthenone Description

Source:	The herbs of Murraya exotica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Osthenone
Price:
CAS No.:	112789-90-9
Catalog No.:	CFN97853
Molecular Formula:	C₁₄H₁₂O₄
Molecular Weight:	244.24 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The herbs of Murraya exotica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0943 mL	20.4717 mL	40.9433 mL	81.8867 mL	102.3583 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL	16.3773 mL	20.4717 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL	8.1887 mL	10.2358 mL
50 mM	0.0819 mL	0.4094 mL	0.8189 mL	1.6377 mL	2.0472 mL
100 mM	0.0409 mL	0.2047 mL	0.4094 mL	0.8189 mL	1.0236 mL

CFN97853	Osthenone	112789-90-9	244.24	C₁₄H₁₂O₄
CFN97823	Isomurralonginol acetate	139115-59-6	302.33	C₁₇H₁₈O₅
CFN98881	Murralongin	53011-72-6	258.3	C₁₅H₁₄O₄
CFN91562	2'E-3'-formaldehydylosthole	73292-92-9	258.3	C₁₅H₁₄O₄
CFN99429	Toddalosin	137182-37-7	562.6	C₃₂H₃₄O₉