Paederosidic acid methyl ester | CAS:122413-01-8

Paederosidic acid methyl ester

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Description:

Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.

Targets:

NO | ATPase | Potassium Channel

In vivo:

Pharmacol Biochem Behav. 2009 Aug;93(2):97-104.

Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.[Pubmed: 19409921]

Antinociceptive activity of Paederosidic acid methyl ester (PAME), a chemical compound isolated from the n-butanol fraction of Paederia scandens, was evaluated in mice using chemical and thermal models of nociception.
METHODS AND RESULTS:
Paederosidic acid methyl ester given by intraperitoneal injection at doses of 20, 40 and 60 mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin or capsaicin injections and on thermal nociception in the tail-flick test and the hot plate test. In the pentobarbital sodium-induced sleep time test and the open-field test, Paederosidic acid methyl ester neither significantly enhanced the pentobarbital sodium-induced sleep time nor impaired the motor performance, indicating that the observed antinociceptive activity of Paederosidic acid methyl ester was unlikely due to sedation or motor abnormality. Core body temperature measurement showed that Paederosidic acid methyl ester did not affect temperature within a 2-h period. Moreover, Paederosidic acid methyl ester-induced antinociception in the hot plate test was insensitive to naloxone or nimodipine but significantly antagonized by L-NAME (N (G)-nitro-L-arginine methyl ester), methylene blue and glibenclamide.
CONCLUSIONS:
These results suggested that Paederosidic acid methyl ester-produced antinociception was possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels, which merited further studies regarding the precise site and mechanisms of action.

Paederosidic acid methyl ester Description

Source:	The herbs of Paederia scandens (Lour.) Merr
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Paederosidic acid methyl ester
Price:	$288 / 20mg
CAS No.:	122413-01-8
Catalog No.:	CFN92525
Molecular Formula:	C₁₉H₂₆O₁₂S
Molecular Weight:	478.5 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The herbs of Paederia scandens (Lour.) Merr
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-nociceptive Compound Library Iridoids Compound Library Potassium Channel Inhibitor Library NO Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0899 mL	10.4493 mL	20.8986 mL	41.7973 mL	52.2466 mL
5 mM	0.418 mL	2.0899 mL	4.1797 mL	8.3595 mL	10.4493 mL
10 mM	0.209 mL	1.0449 mL	2.0899 mL	4.1797 mL	5.2247 mL
50 mM	0.0418 mL	0.209 mL	0.418 mL	0.8359 mL	1.0449 mL
100 mM	0.0209 mL	0.1045 mL	0.209 mL	0.418 mL	0.5225 mL

CFN99142	Genipin	6902-77-8	226.23	C₁₁H₁₄O₅
CFN98261	Geniposide	24512-63-8	388.4	C₁₇H₂₄O₁₀
CFN98524	Genipin-1-O-gentiobioside	29307-60-6	550.51	C₂₃H₃₄O₁₅
CFN98241	Theviridoside	23407-76-3	404.4	C₁₇H₂₄O₁₁
CFN98330	Feretoside	27530-67-2	404.4	C₁₇H₂₄O₁₁
CFN92359	Deacetylasperulosidic acid methyl ester	52613-28-2	404.4	C₁₇H₂₄O₁₁
CFN96738	6-Ethoxygeniposide	1264496-61-8	432.42	C₁₉H₂₈O₁₁
CFN99468	Daphylloside	14260-99-2	446.4	C₁₉H₂₆O₁₂
CFN92525	Paederosidic acid methyl ester	122413-01-8	478.5	C₁₉H₂₆O₁₂S
CFN97953	10-O-Caffeoyl-6-epiferetoside	83348-22-5	566.5	C₂₆H₃₀O₁₄