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Pterisolic acid B
Pterisolic acid B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Pterisolic acid B
Price:
CAS No.: 1401419-86-0
Catalog No.: CFN97976
Molecular Formula: C20H26O4
Molecular Weight: 330.4 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Pteris semipinnata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Pterisolic acid B (J19) is an effective Nrf2 activator. we have also identified a more potent natural product analogue J19-1, J19-1 shows significant cytoprotective effect against cisplatin-induced cytotoxicity in HKC cells.
Targets: Nrf2
In vitro:
Sci. Rep.-UK, 2016, 6,19231.
Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain[Pubmed: PMC4725373]
The use of chemoprotective agents to minimize the side effects of the chemotherapy, primarily via activation of the Nrf2 pathway, is an emerging research field, which has attracted broad attention from both academia and pharmaceutical industry.
METHODS AND RESULTS:
Through high-throughput chemical screens we have disclosed that Pterisolic acid B (J19), a naturally occuring diterpenoid, is an effective Nrf2 activator. We have also identified a more potent natural product analogue J19-1 by semisynthesis and the subsequent biochemical evaluations revealed that J19-1 activates the Nrf2 pathway by covalently modifying Cys171 of keap1, which inhibits Nrf2 degradation mediated by Keap1-Cul3 complexes.
CONCLUSIONS:
Ultimately, we have demonstrated that J19-1 shows significant cytoprotective effect against cisplatin-induced cytotoxicity in HKC cells.
Pterisolic acid B Description
Source: The herbs of Pteris semipinnata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0266 mL 15.1332 mL 30.2663 mL 60.5327 mL 75.6659 mL
5 mM 0.6053 mL 3.0266 mL 6.0533 mL 12.1065 mL 15.1332 mL
10 mM 0.3027 mL 1.5133 mL 3.0266 mL 6.0533 mL 7.5666 mL
50 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.2107 mL 1.5133 mL
100 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.6053 mL 0.7567 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN96331ent-16-Kaurene-3beta,15beta,18-triol921211-29-2320.5C20H32O3
CFN97780Grandifloric acid22338-69-8318.46C20H30O3
CFN97131Deacetylxylopic acid6619-95-0318.5 C20H30O3
CFN9897711,15-Dihydroxy-16-kauren-19-oic acid57719-76-3334.5 C20H30O4
CFN97261ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid77658-39-0332.4 C20H28O4
CFN97294ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid81264-00-8348.4 C20H28O5
CFN89107ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide59885-89-1346.42C20H26O5
CFN97975Pterisolic acid A1401419-85-9346.4C20H26O5
CFN97976Pterisolic acid B1401419-86-0330.4C20H26O4
CFN89078ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid57719-81-0332.44C20H28O4
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