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Retronecine N-oxide
Retronecine N-oxide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Retronecine N-oxide
Price:
CAS No.: 6870-33-3
Catalog No.: CFN00323
Molecular Formula: C8H13NO3
Molecular Weight: 171.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Arnebia euchroma
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vivo:
Toxicol Ind Health. 2008 Apr;24(3):181-8.
Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.[Pubmed: 18842697 ]
The metabolism of Retronecine N-oxide under similar conditions also formed the similar set of DHP-DNA adducts.
METHODS AND RESULTS:
The level of DNA adducts from retronecine was enhanced when metabolism by liver microsomes from phenobarbital (PB)-induced rats were used. The DHP-DNA adducts were also found in the liver DNA of female F344 rats treated with retronecine or Retronecine N-oxide. The highest level of the total DHP-DNA adducts was found in liver DNA from the rats treated with dehydroretronecine (DHR). The order of the levels of DNA adducts in the liver DNA samples from rats treated with various pyrrolizidine alkaloids was: DHR > riddelliine > riddelliine N-oxide >> retronecine > Retronecine N-oxide.
CONCLUSIONS:
The results indicate that 1) retronecine can be metabolized to form DHP by rat liver microsomal enzymes and interacts with DNA to produce DHP-DNA adducts and 2) Retronecine N-oxide undergoes the biotransformation to the parent compound, retronecine. The results from this and our previous findings strongly suggest that formation of DHP-DNA adducts may be a potential biomarker for pyrrolizidine alkaloid carcinogenesis.
Retronecine N-oxide Description
Source: The roots of Arnebia euchroma
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.8411 mL 29.2056 mL 58.4112 mL 116.8224 mL 146.028 mL
5 mM 1.1682 mL 5.8411 mL 11.6822 mL 23.3645 mL 29.2056 mL
10 mM 0.5841 mL 2.9206 mL 5.8411 mL 11.6822 mL 14.6028 mL
50 mM 0.1168 mL 0.5841 mL 1.1682 mL 2.3364 mL 2.9206 mL
100 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.1682 mL 1.4603 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
o-Methoxycinnamaldehyde

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CAS No: 1504-74-1
Price: $40/20mg
Lupeol

Catalog No: CFN98913
CAS No: 545-47-1
Price: $40/20mg
Aucubin

Catalog No: CFN98530
CAS No: 479-98-1
Price: $60/20mg
Madecassoside

Catalog No: CFN99913
CAS No: 34540-22-2
Price: $40/20mg
Inokosterone

Catalog No: CFN92515
CAS No: 15130-85-5
Price: $ / mg
Galangin

Catalog No: CFN98918
CAS No: 548-83-4
Price: $40/20mg
beta-Amyrin

Catalog No: CFN98935
CAS No: 559-70-6
Price: $ /
2'-Hydroxydaidzein

Catalog No: CFN97687
CAS No: 7678-85-5
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Isorhamnetin-3-O-beta-D-Glucoside

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Oxymatrine

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