Retronecine N-oxide | CAS:6870-33-3 | Manufacturer ChemFaces

Retronecine N-oxide

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Description:

Reference standards.

In vivo:

Toxicol Ind Health. 2008 Apr;24(3):181-8.

Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.[Pubmed: 18842697 ]

The metabolism of Retronecine N-oxide under similar conditions also formed the similar set of DHP-DNA adducts.
METHODS AND RESULTS:
The level of DNA adducts from retronecine was enhanced when metabolism by liver microsomes from phenobarbital (PB)-induced rats were used. The DHP-DNA adducts were also found in the liver DNA of female F344 rats treated with retronecine or Retronecine N-oxide. The highest level of the total DHP-DNA adducts was found in liver DNA from the rats treated with dehydroretronecine (DHR). The order of the levels of DNA adducts in the liver DNA samples from rats treated with various pyrrolizidine alkaloids was: DHR > riddelliine > riddelliine N-oxide >> retronecine > Retronecine N-oxide.
CONCLUSIONS:
The results indicate that 1) retronecine can be metabolized to form DHP by rat liver microsomal enzymes and interacts with DNA to produce DHP-DNA adducts and 2) Retronecine N-oxide undergoes the biotransformation to the parent compound, retronecine. The results from this and our previous findings strongly suggest that formation of DHP-DNA adducts may be a potential biomarker for pyrrolizidine alkaloid carcinogenesis.

Retronecine N-oxide Description

Source:	The roots of Arnebia euchroma
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Retronecine N-oxide
Price:
CAS No.:	6870-33-3
Catalog No.:	CFN00323
Molecular Formula:	C₈H₁₃NO₃
Molecular Weight:	171.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Arnebia euchroma
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.8411 mL	29.2056 mL	58.4112 mL	116.8224 mL	146.028 mL
5 mM	1.1682 mL	5.8411 mL	11.6822 mL	23.3645 mL	29.2056 mL
10 mM	0.5841 mL	2.9206 mL	5.8411 mL	11.6822 mL	14.6028 mL
50 mM	0.1168 mL	0.5841 mL	1.1682 mL	2.3364 mL	2.9206 mL
100 mM	0.0584 mL	0.2921 mL	0.5841 mL	1.1682 mL	1.4603 mL

CFN00273	Isotussilagine	91108-32-6	199.25	C₁₀H₁₇NO₃
CFN00274	Pyrrolam B	126424-77-9	155.20	C₈H₁₃NO₂
CFN00297	Otonecine	6887-34-9	185.22	C₉H₁₅NO₃
CFN00308	Chysin A	22269-11-0	169.22	C₉H₁₅NO₂
CFN00322	Retronecine	480-85-3	155.20	C₈H₁₃NO₂
CFN00323	Retronecine N-oxide	6870-33-3	171.2	C₈H₁₃NO₃
CFN00455	Heliotridine	520-63-8	155.2	C₈H₁₃NO₂
CFN00456	Heliotridine N-oxide	N/A	171.2	C₈H₁₃NO₃
CFN00341	Australine	118396-02-4	189.21	C₈H₁₅NO₄
CFN00342	Alexine	116174-63-1	189.21	C₈H₁₅NO₄