Roburic acid | CAS:6812-81-3 | Manufacturer ChemFaces

Roburic acid

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Roburic acid
Price:	$158 / 20mg
CAS No.:	6812-81-3
Catalog No.:	CFN98562
Molecular Formula:	C₃₀H₄₈O₂
Molecular Weight:	440.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	White powder
Source:	The roots of Gentiana macrophylla
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $42.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.

Targets:

COX

In vitro:

Pharmacol Res. 2010 Jun;61(6):519-24.

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.[Pubmed: 20188172]

METHODS AND RESULTS:
Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) using pulsed ultrafiltration liquid chromatography-mass spectrometry, and a mass spectrometry-based enzyme assay was used to determine the concentration of each of 17 ligands that inhibited COX-1 or COX-2 by 50% (IC(50)). Acetyl-11-keto-beta-boswellic acid, beta-boswellic acid, acetyl-alpha-boswellic acid, acetyl-beta-boswellic acid, and betulinic acid were COX-1 selective inhibitors with IC(50) values of approximately 10 microM. Senkyunolide O and cryptotanshinone were COX-2 selective inhibitors with IC(50) values of 5 microM and 22 microM, respectively.
CONCLUSIONS:
Roburic acid and phenethyl-trans-ferulate inhibited COX-1 and COX-2 equally. COX inhibition and the IC(50) values of most of these natural product ligands have not been reported previously.

Roburic acid Description

Source:	The roots of Gentiana macrophylla
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2005 Oct;30(19):1519-22.

Studies on the chemical constituents in root of Gentiana macrophylla from Shaanxi[Pubmed: 16335823]

To in vestigate the constituents in root of Gentiana macrophylla.
METHODS AND RESULTS:
Various column chromatographic techniques were used for isolation and purification of the principles. The structures were elucidated on the basis of spectral data (UV, IR, MS, 1H-, 13C-NMR etc.) and identified by comparing with standard substance. Eight compounds were identified. Four compounds isolated from the chloroform fraction are: 5-carboxyl-3,4-dihydrogen-1H-2-benzopyran-1-one (1), erythrocentauric acid (2), Roburic acid (3), oleanolic acid (4). Water fraction gave four known secoiridoid glucosides. They were: gentiopicroside (5), swertiamarine (6), sweroside (7), 6'-O-beta-D-glucosylgentiopicroside (8).
CONCLUSIONS:
1 is a novel compound. It was named as erythrocentauric acid. 2 was isolated from genus Gentiana and 8 was isolated from G. macrophylla for the first time.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3453 mL	22.6907 mL	45.3813 mL	56.7266 mL
5 mM	0.4538 mL	2.2691 mL	4.5381 mL	9.0763 mL	11.3453 mL
10 mM	0.2269 mL	1.1345 mL	2.2691 mL	4.5381 mL	5.6727 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1345 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL

CFN90531	3-O-Acetyl-11-keto-beta-boswellic acid	67416-61-9	512.72	C₃₂H₄₈O₅
CFN95335	9,11-Dehydro-beta-boswellic acid	471-65-8	454.7	C₃₀H₄₆O₃
CFN70260	3-O-Acetyl 9,11-dehydro beta-boswellic acid	122651-20-1	496.7	C₃₂H₄₈O₄
CFN98562	Roburic acid	6812-81-3	440.71	C₃₀H₄₈O₂
CFN97681	Dulcioic acid	78516-69-5	456.71	C₃₀H₄₈O₃
CFN99881	Triptocallic acid A	190906-61-7	472.7	C₃₀H₄₈O₄
CFN99821	22-Hydroxy-3-oxo-12-ursen-30-oic acid	173991-81-6	470.7	C₃₀H₄₆O₄
CFN90221	Beta-boswellic acid	631-69-6	456.70	C₃₀H₄₈O₃
CFN90530	3-O-Acetyl-beta-boswellic acid	5968-70-7	498.74	C₃₂H₅₀O₄
CFN90152	11-Keto-beta-boswellic acid	17019-92-0	470.68	C₃₀H₄₆O₄