SCH772984 | CAS:942183-80-4 | Manufacturer ChemFaces

SCH772984

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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SCH772984 Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Cancer Discov,2013 Jul;3(7):742-50.

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.[Pubmed: 23614898]

Cell lines:BRAF-mutant or RAS-mutant tumor lines
Concentrations: ~10 μM
Incubation Time: 5 days
Method:
Cell proliferation experiments are performed in a 96-well format (six replicates), and cells are plated at 4,000/well density. At 24 h after cell seeding, cells are treated with DMSO or 9 point IC50 dilution (0.001-10 μM) at 1% DMSO final for all concentrations. Viability is assayed on 5 days after dosing using ViaLight luminescence kit following the manufacturer’s recommendations. For cell line panel viability assay, cells are treated with SCH772984 for 4 days and assayed by CellTiterGlo luminescent cell viability assay.

Animal Research:

Cancer Discov,2013 Jul;3(7):742-50.

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.[Pubmed: 23614898]

Animal Models:Nude mice
Dosages: 12.5 mg/kg, 25 mg/kg, 50 mg/kg
Administration: i.p.

Product Name	SCH772984
Price:
CAS No.:	942183-80-4
Catalog No.:	CFN60064
Molecular Formula:	C₃₃H₃₃N₉O₂
Molecular Weight:	587.67 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7016 mL	8.5082 mL	17.0164 mL	34.0327 mL	42.5409 mL
5 mM	0.3403 mL	1.7016 mL	3.4033 mL	6.8065 mL	8.5082 mL
10 mM	0.1702 mL	0.8508 mL	1.7016 mL	3.4033 mL	4.2541 mL
50 mM	0.034 mL	0.1702 mL	0.3403 mL	0.6807 mL	0.8508 mL
100 mM	0.017 mL	0.0851 mL	0.1702 mL	0.3403 mL	0.4254 mL

CFN89550	Delgrandine	145237-05-4	741.77	C₄₁H₄₃NO₁₂
CFN95101	1-Methyl-2,8-dihydroxy-3-carboxy-9,10-anthraquinone	1401414-53-6	298.3	C₁₆H₁₀O₆
CFN99233	1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid	113558-03-5	504.7	C₃₀H₄₈O₆
CFN93166	6'-O-Cinnamoylharpagide	1245572-24-0	494.49	C₂₄H₃₀O₁₁