Salvianolic acid F | CAS:158732-59-3 | Manufacturer ChemFaces

Salvianolic acid F

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $236.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Salvianolic acid F Description

Source:	The roots of Salvia miltiorrhiza Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Eur. J. Org. Chem., 2016, 36:5941–9.

Divergent Synthesis of Styryl–Cinnamate Hybrid Analogues Inspired by the Natural Product Salvianolic Acid F as a Premise To Investigate Their Anticancer Activity and Its Metabolomic Profiling[Reference: WebLink]

The natural product Salvianolic acid F- inspired protecting-group-free synthesis of hydroxylated styryl-cinnamate hybrids (C6-C2-C6-C3 unit) has been achieved by step-economical route via sequential double C-C bond formation in one pot.
METHODS AND RESULTS:
The present method involves multiple reactions (Perkin-condensation/ decarboxylation-Heck cross-coupling reactions) using simple precursors (i.e. hydroxylated benzaldehyde, arylacetic acid and acrylic acid derivatives) in one pot which yields desired unnatural small hybrid molecules (1-12) in varying yields of 35-65%with E-selectivity under microwave irradiation whereas the reported conventional route for synthesis of Salvianolic acid F itself requires six steps with an overall yield of 10.0% besides tedious separation of E/Z isomers that arise from Wittig reaction.Apart from an economical synthesis and products diversity, we herein report the potential of some hybrid molecules (3,8,10 and 11), with the catecholic core, to selectively inhibit glioma cells. The intrinsic mode of action (MOA) for our lead molecule involving caspase 6 and quinonemethide pathway is also reported based on 1HNMR-guided metabolomic profiling.
CONCLUSIONS:
We emphatically demonstrate the role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.

Product Name	Salvianolic acid F
Price:	$338 / 5mg
CAS No.:	158732-59-3
Catalog No.:	CFN90811
Molecular Formula:	C₁₇H₁₄O₆
Molecular Weight:	314.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Salvia miltiorrhiza Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library Caspase Inhibitor Library

Description:	The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.
Targets:	Caspase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1817 mL	15.9084 mL	31.8167 mL	63.6335 mL	79.5418 mL
5 mM	0.6363 mL	3.1817 mL	6.3633 mL	12.7267 mL	15.9084 mL
10 mM	0.3182 mL	1.5908 mL	3.1817 mL	6.3633 mL	7.9542 mL
50 mM	0.0636 mL	0.3182 mL	0.6363 mL	1.2727 mL	1.5908 mL
100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.6363 mL	0.7954 mL

CFN92426	Isorhapotogenin	32507-66-7	258.3	C₁₅H₁₄O₄
CFN97824	Tristin	139101-67-0	260.29	C₁₅H₁₆O₄
CFN92607	Rhapontigenin	500-65-2	258.3	C₁₅H₁₄O₄
CFN98569	Rhaponiticin	155-58-8	420.39	C₂₁H₂₄O₉
CFN91655	Isorhapontin	32727-29-0	420.4	C₂₁H₂₄O₉
CFN90749	Rhapontigenin 3'-O-glucoside	94356-22-6	420.4	C₂₁H₂₄O₉
CFN90750	Piceatannol 3'-O-glucoside	94356-26-0	406.4	C₂₀H₂₂O₉
CFN92486	Astringin	29884-49-9	406.4	C₂₀H₂₂O₉
CFN90204	Erianin	95041-90-0	318.36	C₁₈H₂₂O₅
CFN91470	Chrysotobibenzyl	108853-09-4	332.4	C₁₉H₂₄O₅