In vitro: |
Pharmaceutical Biology, 1999 , 37 (2) :148-151. | Cytotoxic Activity of Diterpenoids Isolated from Salvia hypargeia[Reference: WebLink] | Ten diterpenoids [6a-hydroxysalvinolone ( 1 ), 6a-hydroxytaxodone ( 2 ), aethiopinone ( 3 ), microstegiol ( 4 ), ferruginol ( 5 ), Saprorthoquinone ( 6 ), 11,12-dioxoabieta-8,13-diene ( 7 ), taxodione ( 8 ), hypargenin A ( 9 ), hypargenin D ( 10 )] and three triterpenoids [lupeol 3-acetate, d-oleanol 3-acetate and -sitosterol] were isolated from the roots of Salvia hypargeia , a plant endemic to Turkey.
METHODS AND RESULTS:
The crude extract and compounds 1-2 , 5-10 were tested against a panel of human cancer cell lines [human breast cancer (BC 1), human lung cancer (LU 2), human colon cancer (COL 2), human epidermoidal carcinoma in mouth (KB), vinblastine-resistant KB-VI, hormone-dependent human prostate cancer (LNCaP)] as well as P388 and ASK cells in culture.
CONCLUSIONS:
The crude extract was active in all of the test systems, except KB. Isolates 1 and 8 were also found to mediate a generalized cytotoxic response. |
|