Science | Nature | Cell | View More
Natural Products
Scandoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Scandoside
Price:
CAS No.: 18842-99-4
Catalog No.: CFN92535
Molecular Formula: C16H22O11
Molecular Weight: 390.3 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Powder
Source: The herbs of Paederia scandens (Lour.) Merr
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University Medical Center Mainz (Germany)
  • Medical University of South Car... (USA)
  • Universit?t Basel (Switzerland)
  • University of Parma (Italy)
  • VIT University (India)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Amity University (India)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Aveiro University (Portugal)
  • Florida A&M University (USA)
  • University of Illinois (USA)
  • More...
Package
Featured Products
Swertisin

Catalog No: CFN90621
CAS No: 6991-10-2
Price: $228/10mg
Isoastragaloside I

Catalog No: CFN90977
CAS No: 84676-88-0
Price: $268/10mg
Myrcene

Catalog No: CFN70046
CAS No: 123-35-3
Price: $30/20mg
(20S)-Protopanaxdiol

Catalog No: CFN99764
CAS No: 30636-90-9
Price: $30/20mg
Peonidin chloride

Catalog No: CFN92034
CAS No: 134-01-0
Price: $380/5mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
Tetrahydrocurcumin

Catalog No: CFN90583
CAS No: 36062-04-1
Price: $30/20mg
Matrine

Catalog No: CFN98835
CAS No: 519-02-8
Price: $30/20mg
Cardamonin

Catalog No: CFN99890
CAS No: 19309-14-9
Price: $40/20mg
Citreorosein

Catalog No: CFN98750
CAS No: 481-73-2
Price: $ /
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Scandoside exerts anti-inflammatory effect via suppressing NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation.
Targets: MAPK | NF-κB
In vitro:
Archives of Pharmacal Research, 2005, 28(10):1156-1160.
Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation.[Reference: WebLink]

METHODS AND RESULTS:
An iridoid glycoside, oldenlandoside III ( 5 ) was isolated from the n -butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb, along with six others previously characterized iridoid glycosides; geniposidic acid ( 1 ), Scandoside ( 2 ), feretoside ( 3 ), 10- O -benzoylScandoside methyl ester ( 4 ), asperulosidic acid ( 6 ) and deacetylasperulosidic acid ( 7 ).
CONCLUSIONS:
Compounds 1, 2 , and 7 inhibited LDL-oxidation, and showed 63.3±2.0, 62.2±1.6, and 63.8±1.5% inhibition, respectively, at a concentration of 20 μg/mL.
Zeitschrift für Naturforschung C, 2007, 62(7-8):597---602.
Iridoid glucosides with insecticidal activity from Galium melanantherum.[Reference: WebLink]
The insecticidal activity of the endemic species Galium melanantherum was evaluated against Crematogaster scutellaris ants and Kalotermes flavicollis termites.
METHODS AND RESULTS:
Iridoid glucosides 1-7 were isolated for the first time as metabolites of the investigated plant, along with the coumarin scopolin. The main components of the extract were found to be the non-acetylated iridoids: geniposidic acid (1), 10-hydroxyloganin (2), deacetyldaphylloside (3), monotropein (4), deacetylasperulosidic acid (5) and Scandoside (6), while asperulosidic acid (7) was present only in minute quantities. All isolated metabolites were identified on the basis of their spectral data.
CONCLUSIONS:
Laboratory bioassays revealed significant levels of toxicity for 1-4 against Kalotermes flavicollis termites and Crematogaster scutellaris ants.
Scandoside Description
Source: The herbs of Paederia scandens (Lour.) Merr
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Nortrachelogenin-5'-C-beta-glucosi...

Catalog No: CFN95251
CAS No: 858127-39-6
Price: $318/10mg
Methyl ganoderate A

Catalog No: CFN95550
CAS No: 105742-78-7
Price: $413/5mg
13(S)-Hydroxyoctadeca-9(Z),11(E)-d...

Catalog No: CFN95307
CAS No: 18104-45-5
Price: $318/10mg
Quercetin 3-O-beta-(6''-p-coumaroy...

Catalog No: CFN95088
CAS No: 143061-65-8
Price: $338/10mg
Caraganaphenol A

Catalog No: CFN95093
CAS No: 174916-31-5
Price: $333/5mg
3,4-O-dimethylcedrusin

Catalog No: CFN95026
CAS No: 166021-14-3
Price: $388/10mg
Schisphenlignan I

Catalog No: CFN95586
CAS No: 1542234-14-9
Price: $318/5mg
Irigenin 3'-O-glucoside

Catalog No: CFN95578
CAS No: N/A
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5621 mL 12.8107 mL 25.6213 mL 51.2426 mL 64.0533 mL
5 mM 0.5124 mL 2.5621 mL 5.1243 mL 10.2485 mL 12.8107 mL
10 mM 0.2562 mL 1.2811 mL 2.5621 mL 5.1243 mL 6.4053 mL
50 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.0249 mL 1.2811 mL
100 mM 0.0256 mL 0.1281 mL 0.2562 mL 0.5124 mL 0.6405 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
International Journal of Molecular Sciences, 2018, 19(2):457.
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.[Reference: WebLink]
The iridoids of Hedyotis diffusa Willd play an important role in the anti-inflammatory process, but the specific iridoid with anti-inflammatory effect and its mechanism has not be thoroughly studied.
METHODS AND RESULTS:
An iridoid compound named Scandoside (SCA) was isolated from H. diffusa and its anti-inflammatory effect was investigated in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Its anti-inflammatory mechanism was confirmed by in intro experiments and molecular docking analyses. As results, SCA significantly decreased the productions of nitric oxide (NO), prostaglandin E₂ (PGE₂), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and inhibited the levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-α and IL-6 messenger RNA (mRNA) expression in LPS-induced RAW 264.7 macrophages. SCA treatment suppressed the phosphorylation of inhibitor of nuclear transcription factor kappa-B alpaha (IκB-α), p38, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). The docking data suggested that SCA had great binding abilities to COX-2, iNOS and IκB.
CONCLUSIONS:
Taken together, the results indicated that the anti-inflammatory effect of SCA is due to inhibition of pro-inflammatory cytokines and mediators via suppressing the nuclear transcription factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways, which provided useful information for its application and development.
Swertisin

Catalog No: CFN90621
CAS No: 6991-10-2
Price: $228/10mg
Isoastragaloside I

Catalog No: CFN90977
CAS No: 84676-88-0
Price: $268/10mg
Myrcene

Catalog No: CFN70046
CAS No: 123-35-3
Price: $30/20mg
(20S)-Protopanaxdiol

Catalog No: CFN99764
CAS No: 30636-90-9
Price: $30/20mg
Peonidin chloride

Catalog No: CFN92034
CAS No: 134-01-0
Price: $380/5mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
Tetrahydrocurcumin

Catalog No: CFN90583
CAS No: 36062-04-1
Price: $30/20mg
Matrine

Catalog No: CFN98835
CAS No: 519-02-8
Price: $30/20mg
Cardamonin

Catalog No: CFN99890
CAS No: 19309-14-9
Price: $40/20mg
Citreorosein

Catalog No: CFN98750
CAS No: 481-73-2
Price: $ /
Tags: buy Scandoside | Scandoside supplier | purchase Scandoside | Scandoside cost | Scandoside manufacturer | order Scandoside | Scandoside distributor