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Scutebata A
Scutebata A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Scutebata A
Price:
CAS No.: 1207181-57-4
Catalog No.: CFN99322
Molecular Formula: C36H40O10
Molecular Weight: 632.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Scutellaria barbata D.Don
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Scutebata A shows weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.
In vitro:
J Nat Prod. 2010 Feb 26;73(2):233-6.
Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Pubmed: 20078074]

METHODS AND RESULTS:
Seven new neoclerodane diterpenoids, Scutebata A-scutebataG (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of Scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1.
CONCLUSIONS:
Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.
Scutebata A Description
Source: The herbs of Scutellaria barbata D.Don
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5805 mL 7.9026 mL 15.8053 mL 31.6106 mL 39.5132 mL
5 mM 0.3161 mL 1.5805 mL 3.1611 mL 6.3221 mL 7.9026 mL
10 mM 0.1581 mL 0.7903 mL 1.5805 mL 3.1611 mL 3.9513 mL
50 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.6322 mL 0.7903 mL
100 mM 0.0158 mL 0.079 mL 0.1581 mL 0.3161 mL 0.3951 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN89211(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al935293-70-2332.44C20H28O4
CFN979906alpha,16,18-Trihydroxycleroda-3,13-dien-15,16-olide1017233-48-5350.5C20H30O5
CFN89104Dodovislactone B1616683-55-6362.46C21H30O5
CFN96683Scutebarbatine Z1312716-28-1439.55C26H33NO5
CFN96686Scutebarbatine Y1312716-27-0557.64C33H35NO7
CFN990286-O-Nicotinoylbarbatin C1015776-92-7453.5 C26H31NO6
CFN97471Scutebarbatine B905929-95-5557.6 C33H35NO7
CFN99832Scutebarbatine A176520-13-1558.6 C32H34N2O7
CFN99324Scutebata C1207181-59-6529.6 C28H35NO9
CFN99323Scutebata B1207181-58-5633.7 C35H39NO10
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