Sempervirine | CAS:6882-99-1 | Manufacturer ChemFaces

Sempervirine

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Description:

Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .

Targets:

DNA/RNA Synthesis

In vitro:

Exp Cell Biol. 1982;50(2):79-87.

Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class.[Pubmed: 7075859]

METHODS AND RESULTS:
The high template in vitro activity of native DNA from cancerous mammalian and plant tissues, compared to DNA from healthy tissues, enabled us to select substances which selectively inhibit cancer DNA synthesis. Among them, alstonine, serpentine, Sempervirine and flavopereirine, all alkaloids which belong to the Beta-carboline class, distinguish cancer DNA from healthy tissue DNA inhibit DNA in vitro synthesis when native DNA from different cancerous tissues or cells is used as template. They have practically no effect on DNA from healthy tissues. The inhibitory effect of alkaloids is due to their capacity to form an 'alkaloid-cancer DNA' complex which has been characterized by use of the Sephadex column.
CONCLUSIONS:
Evidence is presented showing that these alkaloids inhibit the initiation of DNA synthesis but not chain elongation. The stimulating action caused by carcinogens during cancer DNA in vitro synthesis may be prevented and reversed by alkaloids. Furthermore, the stimulating action of steroids during in vitro synthesis of hormone target tissue DNA might be neutralized by alkaloids. However, at relatively high doses, steroids reversibly compete with alkaloids for binding sites on breast cancer DNA. This is not observed with DNA from nonhormone target tissues.

Sempervirine Description

Source:	The herbs of Gelsemium elegans
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Biochimie. 1984 Jan;66(1):31-41.

Physico-chemical investigation of the mode of binding of the alkaloids 5,6-dihydroflavopereirine and sempervirine with DNA.[Pubmed: 6713013]

METHODS AND RESULTS:
The mode of binding of 5,6-dihydroflavopereirine and Sempervirine to DNA has been investigated by absorption spectrophotometry, circular and electric linear dichroism, fluorescence and fluorescence polarization, viscosity increase of sonicated linear DNA and circular DNA unwinding. Although the spectroscopic properties of both compounds bound to DNA resembled those reported in our previous study of DNA complexes with two other alkaloids, and observed with planar intercalating compounds, only Sempervirine was able to unwind circular DNA. The latter drug however showed signs characteristic of aggregation at the surface of the polyion.
CONCLUSIONS:
The differences between the behaviours of the four alkaloids so far investigated by us are interpreted on the basis of different extent of penetration of the chromophore ring into the DNA helix.

Product Name	Sempervirine
Price:
CAS No.:	6882-99-1
Catalog No.:	CFN97173
Molecular Formula:	C₁₉H₁₆N₂
Molecular Weight:	272.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Gelsemium elegans
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Alkaloids Compound Library DNA/RNA Synthesis Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6711 mL	18.3554 mL	36.7107 mL	73.4214 mL	91.7768 mL
5 mM	0.7342 mL	3.6711 mL	7.3421 mL	14.6843 mL	18.3554 mL
10 mM	0.3671 mL	1.8355 mL	3.6711 mL	7.3421 mL	9.1777 mL
50 mM	0.0734 mL	0.3671 mL	0.7342 mL	1.4684 mL	1.8355 mL
100 mM	0.0367 mL	0.1836 mL	0.3671 mL	0.7342 mL	0.9178 mL

CFN97173	Sempervirine	6882-99-1	272.4	C₁₉H₁₆N₂
CFN92577	Allo-Yohimbine	522-94-1	354.5	C₂₁H₂₆N₂O₃
CFN92579	Methyl reserpate	2901-66-8	414.5	C₂₃H₃₀N₂O₅
CFN92580	Reserpinine	24815-24-5	634.7	C₃₅H₄₂N₂O₉
CFN92583	Reserpin N-oxide	474-48-6	624.7	C₃₃H₄₀N₂O₁₀
CFN92610	18-Beta-hydroxy-3-epi-alpha-yohimbine	81703-06-2	370.5	C₂₁H₂₆N₂O₄
CFN98112	Reserpine	50-55-5	608.69	C₃₃H₄₀N₂O₉
CFN98542	Syrosingopine	84-36-6	666.71	C₃₅H₄₂N₂O₁₁
CFN98762	Isorauhimbine	483-09-0	354.5	C₂₁H₂₆N₂O₃
CFN98921	beta-Yohimbine	549-84-8	354.5	C₂₁H₂₆N₂O₃