Sikokianin C | CAS:159813-69-1 | Manufacturer ChemFaces

Sikokianin C

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Description:

Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.

Targets:

NO | NOS | IFN-γ | Antifection

In vitro:

Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9.

Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed: 15635251]

METHODS AND RESULTS:
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression.
CONCLUSIONS:
This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.

Planta Med. 2004 Jan;70(1):76-8.

In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed: 14765300 ]

In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect.
METHODS AND RESULTS:
Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum.
CONCLUSIONS:
This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.

Sikokianin C Description

Source:	The roots of Wikstroemia indica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Sikokianin C
Price:
CAS No.:	159813-69-1
Catalog No.:	CFN96514
Molecular Formula:	C₃₁H₂₄O₁₀
Molecular Weight:	556.52 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Wikstroemia indica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Flavonoids Compound Library NOS Inhibitor Library NO Inhibitor Library IFN-γ Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7969 mL	8.9844 mL	17.9688 mL	35.9376 mL	44.922 mL
5 mM	0.3594 mL	1.7969 mL	3.5938 mL	7.1875 mL	8.9844 mL
10 mM	0.1797 mL	0.8984 mL	1.7969 mL	3.5938 mL	4.4922 mL
50 mM	0.0359 mL	0.1797 mL	0.3594 mL	0.7188 mL	0.8984 mL
100 mM	0.018 mL	0.0898 mL	0.1797 mL	0.3594 mL	0.4492 mL

CFN92155	Sikokianin A	106293-99-6	556.5	C₃₁H₂₄O₁₀
CFN96514	Sikokianin C	159813-69-1	556.52	C₃₁H₂₄O₁₀
CFN92063	Isochamaejasmenin B	865852-48-8	570.6	C₃₂H₂₆O₁₀
CFN92062	Chamaejasmenin A	89595-71-1	570.6	C₃₂H₂₆O₁₀
CFN92061	Chamaejasmenin C	89595-70-0	584.6	C₃₃H₂₈O₁₀
CFN96558	Ruixianglangdusu B	447454-49-1	584.57	C₃₃H₂₈O₁₀
CFN92064	Chamaejasmenin D	865852-47-7	570.6	C₃₂H₂₆O₁₀
CFN92150	Isochamaejasmine	93859-63-3	542.5	C₃₀H₂₂O₁₀
CFN92153	Isoneochamaejasmine A	871319-96-9	542.5	C₃₀H₂₂O₁₀
CFN92152	Neochamaejasmine B	90411-12-4	542.5	C₃₀H₂₂O₁₀