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Soyasaponin Ac
Soyasaponin Ac
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Soyasaponin Ac
Price:
CAS No.: 133882-74-3
Catalog No.: CFN90774
Molecular Formula: C67H104O32
Molecular Weight: 1421.6 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The seeds of Glycine max
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.
In vitro:
Chinese Pharmacological Bulletin, 2018.
Effect of soyasaponin on drug resistance of ovarian cancer cells.[Reference: WebLink]
To screen the most effective soyasaponins for reversing the drug resistance of ovarian cancer cells,and investigate the possible mechanism.
METHODS AND RESULTS:
Cell viability assay was used to analyze the drug resistance of A2780/PTX cells treated with four different common soyasaponins respectively,in order to screen out the most effective soyasaponin. Then,the most effective soyasaponin was used to detect the expression of epithelial-mesenchymal transition (EMT)-related marker proteins, including N-cadherin and E-cadherin,with Western blot and confocal microscopy. Finally,transwell assay and wound healing assay were applied to observe effect of soyasaponin on regulating cancer cell migration. Compared with other soyasaponins,Soyasaponin Ac most effectively reversed the drug resistance of A2780/PTX cells. The expression of N-cadherin decreased while that of Ecadherin increased in A2780/PTX cells when treated with Soyasaponin Ac for 48 h. The results of transwell and wound healing assay suggested that Soyasaponin Ac also reduced the migration of A2780/PTX cells.
CONCLUSIONS:
Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.
Soyasaponin Ac Description
Source: The seeds of Glycine max
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.7034 mL 3.5172 mL 7.0343 mL 14.0687 mL 17.5858 mL
5 mM 0.1407 mL 0.7034 mL 1.4069 mL 2.8137 mL 3.5172 mL
10 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.4069 mL 1.7586 mL
50 mM 0.0141 mL 0.0703 mL 0.1407 mL 0.2814 mL 0.3517 mL
100 mM 0.007 mL 0.0352 mL 0.0703 mL 0.1407 mL 0.1759 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN90775Soyasaponin Bd135272-91-2957.1C48H76O19
CFN93251Soyasaponin IV108906-97-4767.0C41H66O13
CFN91596Soyasaponin III55304-02-4796.99C42H68O14
CFN93159Soyasaponin II55319-36-3913.1C47H76O17
CFN90456Soyasaponin Bb51330-27-9943.12C48H78O18
CFN90722Soyasaponin Ba114590-20-4959.1C48H78O19
CFN90455Soyasaponin Aa117230-33-81365.46C64H100O31
CFN90773Soyasaponin Ab118194-13-11437.6C67H104O33
CFN90774Soyasaponin Ac133882-74-31421.6C67H104O32
CFN80325Pedunsaponin C272120-53-3795.0C42H66O14
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