Sulfotanshinone IIA Sodium | CAS:N/A | Manufacturer ChemFaces

Sulfotanshinone IIA Sodium

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $14.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Sulfotanshinone IIA Sodium Description

Source:	The roots of Salvia miltiorrhiza Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Cellular Physiology & Biochemistry, 2018:2434-2444.

Sulfotanshinone IIA Sodium Ameliorates Glucose Peritoneal Dialysis Solution-Induced Human Peritoneal Mesothelial Cell Injury via Suppression of ASK1-P38-mediated Oxidative Stress.[Reference: WebLink]

Long-term use of high-glucose peritoneal dialysis solution (PDS) induces peritoneal mesothelial cell (PMC) injury, peritoneal dysfunction, and peritoneal dialysis (PD) failure in patients with end-stage renal disease. How to preserve PMCs in PD is a major challenge for nephrologists worldwide. In this study, we aimed to elucidate the efficacy and mechanisms of Sulfotanshinone IIA Sodium (Tan IIa) in ameliorating high-glucose PDS-induced human PMC injury.
METHODS AND RESULTS:
The human PMC line HMrSV5 was incubated with 4.25% PDS in vitro to mimic the high-glucose conditions in PD. Cellular viability was measured by Cell Counting Kit 8. Generation of superoxide and reactive oxygen species (ROS) was assessed using a Total ROS/Superoxide Detection Kit. Oxidative modification of protein was evaluated by OxyBlot Protein Oxidation Detection Kit. TUNEL (dT-mediated dUTP nick end labeling) assay and DAPI (4,6-diamidino-2-phenylindole) staining were used to evaluate apoptosis. Western blot analysis was performed to evaluate the efficacy and mechanisms of Tan IIa. Tan IIa protected PMCs against PDS-induced injury as evidenced by alleviating changes in morphology and loss of cell viability. Consistent with their antioxidant properties, N-acetyl-L-cysteine (NAC) and Tan IIa suppressed superoxide and ROS production, protein oxidation, and apoptosis elicited by PDS. Apoptosis signal-regulating kinase 1 (ASK1)-p38 signaling was activated by PDS. Both Tan IIa and NAC suppressed ASK1 and p38 phosphorylation elicited by PDS. Moreover, genetic downregulation of ASK1 ameliorated cell injury and inhibited the phosphorylation of p38 and activation of caspase 3.
CONCLUSIONS:
Tan IIa protects PMCs against PDS-induced oxidative injury through suppression of ASK1-p38 signaling.

Product Name	Sulfotanshinone IIA Sodium
Price:	$40 / 20mg
CAS No.:	N/A
Catalog No.:	CFN99162
Molecular Formula:	C₁₉H₁₇NaO₆S
Molecular Weight:	396.39 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Red powder
Source:	The roots of Salvia miltiorrhiza Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library ROS Inhibitor Library Caspase Inhibitor Library

Description:	Sulfotanshinone IIA Sodium protects peritoneal mesothelial cells against PDS-induced oxidative injury through suppression of ASK1-p38 signaling.
Targets:	ASK1-p38 \| ROS \| Caspase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5228 mL	12.6138 mL	25.2277 mL	50.4554 mL	63.0692 mL
5 mM	0.5046 mL	2.5228 mL	5.0455 mL	10.0911 mL	12.6138 mL
10 mM	0.2523 mL	1.2614 mL	2.5228 mL	5.0455 mL	6.3069 mL
50 mM	0.0505 mL	0.2523 mL	0.5046 mL	1.0091 mL	1.2614 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	0.5046 mL	0.6307 mL

CFN92165	1,2-Didehydrotanshinone IIA	119963-50-7	292.3	C₁₉H₁₆O₃
CFN98952	Tanshinone IIA	568-72-9	294.4	C₁₉H₁₈O₃
CFN90353	Hydroxytanshinone IIA	18887-18-8	310.35	C₁₉H₁₈O₄
CFN92022	Przewaquinone A	76843-23-7	310.4	C₁₉H₁₈O₄
CFN90352	3alpha-Hydroxytanshinone IIA	97399-71-8	310.35	C₁₉H₁₈O₄
CFN99820	Tanshinone IIB	17397-93-2	310.4	C₁₉H₁₈O₄
CFN92148	Methyltanshinonate	18867-19-9	338.4	C₂₀H₁₈O₅
CFN99162	Sulfotanshinone IIA Sodium	N/A	396.39	C₁₉H₁₇NaO₆S