Sunset yellow | CAS:2783-94-0 | Manufacturer ChemFaces

Sunset yellow

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Description:

Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care must be taken when using these materials as a food additive.

Targets:

Androgen Receptor

In vitro:

Pak J Pharm Sci. 2015 Jan;28(1):227-30.

Genotoxic and cytotoxic effects of Sunset Yellow and Brilliant Blue, colorant food additives, on human blood lymphocytes.[Pubmed: 25553699]

The synthetic dyes over fifty are used in many areas including the food industry around the world. Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products. The present study investigated the genotoxic and cytotoxic effects of Sunset yellow and Brilliant Blue.
METHODS AND RESULTS:
Genotoxic and cytotoxic activities of the food additives were evaluated in lymphocyte cell cultures using mitotic index, replication index and micronucleus assay. Mitotic index frequencies and replication index values were decreased and micronucleus frequency was increased with increasing concentrations of Sunset yellow and Brilliant Blue. The changes in mitotic index and micronucleus are statistically significant (p<0.05).
CONCLUSIONS:
The results show that the Sunset yellow and Brilliant Blue can have cytotoxic and genotoxic potential. It care must be taken when using these materials as a food additive.

Talanta. 2012 Sep 15;99:125-31.

Development of a polyclonal antibody-based enzyme-linked immunosorbent assay (ELISA) for detection of Sunset Yellow FCF in food samples.[Pubmed: 22967531]

Sunset yellow FCF is widely used as food additives to make foods more attractive. Due to its abuse and potential risk to human health, Sunset yellow FCF is precisely limited to use in food.
METHODS AND RESULTS:
To monitor the illegal use of Sunset yellow FCF, a polyclonal antibody-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) with satisfactory sensitivity and specificity was developed. A carboxyl group was introduced to Sunset yellow FCF, then the modified hapten was coupled with carrier proteins to synthesize the immunogen and coating antigen. The IC(50) value of 0.52 ng mL(-1) and detection limit of 25 pg mL(-1) (in buffer) were achieved by this method. The cross-reactivity values of the antibodies with six structurally related colorants were less than 1.5%, indicating the high selectivity. Three kinds of food samples (beverage, dried beancurd, braised pork) and serum were chosen to evaluate the application of the immunoassay in real systems. The limits of detection (LOD) in the above three food samples were 0.12, 0.04 and 1.11, respectively (mean+3SD). The recovery (94%-106%), intra-assay (<5%) and inter-assay (<12%) coefficients of variation in foods and serum samples were also acceptable.
CONCLUSIONS:
The results suggest that this ELISA method is a specific, sensitive and simple method for the determination of Sunset yellow FCF additives.

Sunset yellow Description

Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Magn Reson Chem. 2014 Aug;52(8):435-9.

Investigating the interaction of sunset yellow aggregates and 6-fluoro-2-naphthoic acid: increasing probe molecule complexity.[Pubmed: 24861207]

The interaction of small molecules with non-covalent assemblies is of wide interest. The use of a magnetically active reporter nucleus allows information to be obtained in the presence of spectral overlap or in cases of high dynamic range. In this paper, we explore the interaction of a larger probe molecule, 6-fluoro-2-naphthoic acid with assemblies of Sunset yellow using (19)F chemical shifts and diffusion NMR methods. Comparing the observations with previous studies using fluorophenols, 6-fluoro-2-naphthoic acid prefers to associate as clusters at the ends of the Sunset yellow stacks.

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 5;134:1-9.

Artificial neural network (ANN) method for modeling of sunset yellow dye adsorption using zinc oxide nanorods loaded on activated carbon: Kinetic and isotherm study.[Pubmed: 24995412]

In this research, ZnO nanoparticle loaded on activated carbon (ZnO-NPs-AC) was synthesized simply by a low cost and nontoxic procedure.
METHODS AND RESULTS:
The characterization and identification have been completed by different techniques such as SEM and XRD analysis. A three layer artificial neural network (ANN) model is applicable for accurate prediction of dye removal percentage from aqueous solution by ZnO-NRs-AC following conduction of 270 experimental data. The network was trained using the obtained experimental data at optimum pH with different ZnO-NRs-AC amount (0.005-0.015 g) and 5-40 mg/L of Sunset yellow dye over contact time of 0.5-30 min. The ANN model was applied for prediction of the removal percentage of present systems with Levenberg-Marquardt algorithm (LMA), a linear transfer function (purelin) at output layer and a tangent sigmoid transfer function (tansig) in the hidden layer with 6 neurons. The minimum mean squared error (MSE) of 0.0008 and coefficient of determination (R(2)) of 0.998 were found for prediction and modeling of SY removal.
CONCLUSIONS: The influence of parameters including adsorbent amount, initial dye concentration, pH and contact time on Sunset yellow (SY) removal percentage were investigated and optimal experimental conditions were ascertained. Optimal conditions were set as follows: pH, 2.0; 10 min contact time; an adsorbent dose of 0.015 g. Equilibrium data fitted truly with the Langmuir model with maximum adsorption capacity of 142.85 mg/g for 0.005 g adsorbent. The adsorption of Sunset yellow followed the pseudo-second-order rate equation.

Product Name	Sunset yellow
Price:	$30 / 20mg
CAS No.:	2783-94-0
Catalog No.:	CFN90065
Molecular Formula:	C₁₆H₁₀N₂Na₂O₇S₂
Molecular Weight:	452.37 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Yellow powder
Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Food additives Compound Library Pigments Compound Library Genotoxicity Compound Library Miscellaneous Compound Library Androgen Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2106 mL	11.0529 mL	22.1058 mL	44.2116 mL	55.2645 mL
5 mM	0.4421 mL	2.2106 mL	4.4212 mL	8.8423 mL	11.0529 mL
10 mM	0.2211 mL	1.1053 mL	2.2106 mL	4.4212 mL	5.5264 mL
50 mM	0.0442 mL	0.2211 mL	0.4421 mL	0.8842 mL	1.1053 mL
100 mM	0.0221 mL	0.1105 mL	0.2211 mL	0.4421 mL	0.5526 mL

CFN90063	Allura Red AC	25956-17-6	496.42	C₁₈H₁₄N₂Na₂O₈S₂
CFN90065	Sunset yellow	2783-94-0	452.37	C₁₆H₁₀N₂Na₂O₇S₂
CFN90067	Riboflavine	83-88-5	376.36	C₁₇H₂₀N₄O₆
CFN90117	Indoxacarb	144171-61-9	527.83	C₂₂H₁₇ClF₃N₃O₇
CFN90239	Indirubin	479-41-4	262.26	C₁₆H₁₀N₂O₂
CFN98513	Quetiapine fumarate	111974-72-2	883.09	(C₂H₂₁N₂₅O₃S).C₂H₄O₄₄
CFN98514	Quetiapine hydroxy impurity	329216-67-3	339.46	C₁₉H₂₁N₃OS
CFN99948	Bilirubin	635-65-4	584.66	C₃₃H₃₆N₄O
CFN90018	Ezetimibe	163222-33-1	409.43	C₂₄H₂₁F₂NO₃
CFN90020	Roflumilast	162401-32-3	403.21	C₁₇H₁₄Cl₂F₂N₂O₃