Taxuspine B | CAS:157414-05-6 | Manufacturer ChemFaces

Taxuspine B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Taxuspine B is a natural product from the Japanese yew Taxus cuspidata Sieb. et Zucc.

In vitro:

Tetrahedron, 1994, 50(25):7401-7416。

Taxuspines A ～ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells[Reference: WebLink]

METHODS AND RESULTS:
Three new taxoids, taxuspine A, Taxuspine B, taxuspine C (1 ～ 3), possessing different skeletons from usual taxane diterpenoids consisting of a 6/8/6-membered ring system have been isolated together with known taxoids (4 ～ 12) from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc. and the structures elucidated on the basis of spectroscopic data. Most of the taxoids increased cellular accumulation of vincristine in multidrug-resistant tumor cells, while taxol (12) did not show such an activity. The taxoids (1 ～ 11) showed no or weak cytotoxicity and among them, 2（Taxuspine B） and 6 reduced appreciably CaCI2-induced depolymerization of microtubules.
CONCLUSIONS:
These results suggest that some taxoids may be useful for overcoming multidrug resistance in tumor cells.

Taxuspine B Description

Source:	The stems of the Japanese yew Taxus cuspidata Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Taxuspine B
Price:
CAS No.:	157414-05-6
Catalog No.:	CFN96630
Molecular Formula:	C₃₅H₄₂O₁₀
Molecular Weight:	622.71 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The stems of the Japanese yew Taxus cuspidata Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6059 mL	8.0294 mL	16.0588 mL	32.1177 mL	40.1471 mL
5 mM	0.3212 mL	1.6059 mL	3.2118 mL	6.4235 mL	8.0294 mL
10 mM	0.1606 mL	0.8029 mL	1.6059 mL	3.2118 mL	4.0147 mL
50 mM	0.0321 mL	0.1606 mL	0.3212 mL	0.6424 mL	0.8029 mL
100 mM	0.0161 mL	0.0803 mL	0.1606 mL	0.3212 mL	0.4015 mL

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