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Taxuspine X
Taxuspine X
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Taxuspine X
Price:
CAS No.: 194782-02-0
Catalog No.: CFN96628
Molecular Formula: C41H50O14
Molecular Weight: 766.83 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The stems of the Japanese yew Taxus cuspidata Sieb. et Zucc.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • University of Pretoria (South Africa)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Taxuspine X may have p-glycoprotein inhibitory activity.
Targets: P-gp
In vitro:
ACS Med Chem Lett. 2010 Jul 15;1(8):416-21.
From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.[Pubmed: 24900226]

METHODS AND RESULTS:
Three simplified "non-natural" natural taxanes, related to Taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. One of them (6) proved to be a very efficient P-gp inhibitor with an IC50 = 7.2 × 10(-6) M. In addition, to rationalize biological data, a pharmacophoric model was built through a ligand-based approach.
CONCLUSIONS:
This model represents the first example of a pharmacophore, which describes interactions of taxanes with P-gp.
Taxuspine X Description
Source: The stems of the Japanese yew Taxus cuspidata Sieb. et Zucc.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3041 mL 6.5204 mL 13.0407 mL 26.0814 mL 32.6018 mL
5 mM 0.2608 mL 1.3041 mL 2.6081 mL 5.2163 mL 6.5204 mL
10 mM 0.1304 mL 0.652 mL 1.3041 mL 2.6081 mL 3.2602 mL
50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5216 mL 0.652 mL
100 mM 0.013 mL 0.0652 mL 0.1304 mL 0.2608 mL 0.326 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1344-6.
Taxane diterpenoids from seeds of Taxus mairei.[Pubmed: 10993234]

METHODS AND RESULTS:
A new 2(3-->20) abeotaxane, taxumairone A (1), and a new cis-p-coumaroyl myo-inositol have been isolated from the seeds of Taxus mairei in addition to taxin B (2), taxinine A, Taxuspine X, decinnamoyltaxinine E, 5alpha-cinnamoyloxy-9alpha,10beta,13alpha- triacetoxy-taxa-4(20)11-diene and 5alpha-cinnamoyloxy-2alpha,9alpha,10beta,+ ++13alpha-tetraacetoxy-taxa-4(20)11-diene. The structure of 1 was determined by 2D-NMR spectral analysis and chemical correlation with taxin B (2).
CONCLUSIONS:
Compound 1 exhibited potent cytotoxicity against human colon carcinoma cells with an ED50 of 0.1 microg/ml.
CFN890515-Epicanadensene220384-17-8594.65C30H42O12
CFN8909613-Deacetyltaxachitriene A239800-99-8594.65C30H42O12
CFN96644Taxachitriene A167906-74-3636.69C32H44O13
CFN891222-Deacetyltaxachitriene A214769-96-7594.65C30H42O12
CFN891195-Acetyltaxachitriene A187988-48-3678.72C34H46O14
CFN96643Taxachitriene B167906-75-4594.65C30H42O12
CFN890812-Deacetyltaxuspine X259678-73-4724.8C39H48O13
CFN8908020-Deacetyltaxuspine X284672-76-0724.8C39H48O13
CFN96628Taxuspine X194782-02-0766.83C41H50O14
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