Science | Nature | Cell | View More
Natural Products
Totaradiol
Totaradiol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Totaradiol
Price:
CAS No.: 3772-56-3
Catalog No.: CFN98610
Molecular Formula: C20H30O2
Molecular Weight: 302.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The heartwoods of Sabina pingii var. wilsonii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
More Impact Factor than five Cite...
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Our products had been exported to the following research institutions and universities, And still growing.
  • Imperial College London (United Kingdom)
  • Universidade Católica Portuguesa (Portugal)
  • Macau University of Science and... (China)
  • Universidade de Franca (Brazil)
  • Kazusa DNA Research Institute (Japan)
  • Sanford Burnham Prebys Medical ... (USA)
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • University of Otago (New Zealand)
  • University of Illinois (USA)
  • Kamphaengphet Rajabhat University (Thailand)
  • Anna University (India)
  • More...
Package
Featured Products
More...
Corosolic acid

Catalog No: CFN98685
CAS No: 4547-24-4
Price: $60/20mg
Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg
Senkyunolide I

Catalog No: CFN99596
CAS No: 94596-28-8
Price: $100/20mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Isovitexin-2''-O-rhamnoside (2''-O...

Catalog No: CFN95314
CAS No: 72036-50-1
Price: $318/5mg
L-Citruline

Catalog No: CFN90551
CAS No: 372-75-8
Price: $30/20mg
3,7-Di-O-methylquercetin

Catalog No: CFN96221
CAS No: 2068-02-2
Price: $/mg
Stevenleaf

Catalog No: CFN99189
CAS No: 80321-63-7
Price: $ / mg
Ganoderic acid B

Catalog No: CFN92052
CAS No: 81907-61-1
Price: $288/20mg
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line.
Targets: NADPH-oxidase
In vitro:
Planta Med. 1997 Jun;63(3):213-5.
Antioxidative action of diterpenoids from Podocarpus nagi.[Pubmed: 9225601]

METHODS AND RESULTS:
Diterpenoids, totarol (1), Totaradiol (2), 19-hydroxytotarol (3), totaral (4), 4 beta-carboxy-19-nortotarol (5), sugiol (6), isolated from Podocarpus nagi, were evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH were inhibited by these terpenoids. They inhibited linoleic acid autoxidation but not generation of superoxide anion. Totarol (1) protected mitochondrial respiratory enzyme activities against NADPH induced oxidative injury.
CONCLUSIONS:
Totarane diterpenes from P. nagi were shown to be effective to protect biological systems and function against various oxidative stresses.
Nat.Prod.Res.,2006, 20(6): 606-10.
Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest.[Pubmed: 16835095]

METHODS AND RESULTS:
Bioassay-directed fractionation of an extract of the root and bark of Podocarpus madagascariensis resulted in the isolation of a new totarol diterpenoid (1) in addition to the three known cytotoxic diterpenoids 19-hydroxytotarol (2), Totaradiol (3), and 4beta-carboxy-19-nor-totarol (4). The structure of the new compound 1 was established as methyl-13-hydroxy-14-isopropyl-9(11),12,14(8)-podocarpatriene-19-oate on the basis of 1D and 2D NMR spectroscopic interpretation and methylation of 4.
CONCLUSIONS:
All the compounds exhibited cytotoxic activity against the A2780 ovarian cancer cell line.
Totaradiol Description
Source: The heartwoods of Sabina pingii var. wilsonii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New Products More...
Calleryanin

Catalog No: CFN95556
CAS No: 20300-53-2
Price: $318/5mg
Octyl 3-(4-hydroxyphenyl)prop-2-en...

Catalog No: CFN95563
CAS No: N/A
Price: $318/5mg
5-Hydroxy-4a,8-dimethyl-3-methylen...

Catalog No: CFN95522
CAS No: 114579-31-6
Price: $318/5mg
Narirutin 4'-glucoside

Catalog No: CFN95421
CAS No: 17257-22-6
Price: $318/10mg
Rhamnocitrin 3-apiosyl-(1->2)-gluc...

Catalog No: CFN95145
CAS No: 148031-68-9
Price: $318/10mg
(Z)-3,11-dimethy-7-methylene-9,14-...

Catalog No: CFN95402
CAS No: 1392202-57-1
Price: $318/10mg
Caraganaphenol A

Catalog No: CFN95093
CAS No: 174916-31-5
Price: $333/5mg
Theaflavanoside II

Catalog No: CFN95380
CAS No: 943785-09-9
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3058 mL 16.5289 mL 33.0579 mL 66.1157 mL 82.6446 mL
5 mM 0.6612 mL 3.3058 mL 6.6116 mL 13.2231 mL 16.5289 mL
10 mM 0.3306 mL 1.6529 mL 3.3058 mL 6.6116 mL 8.2645 mL
50 mM 0.0661 mL 0.3306 mL 0.6612 mL 1.3223 mL 1.6529 mL
100 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.6612 mL 0.8264 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Angew Chem Int Ed Engl. 2015 Mar 2;54(10):3033-7.
Enantioselective palladium-catalyzed dearomative cyclization for the efficient synthesis of terpenes and steroids.[Pubmed: 25631391]

METHODS AND RESULTS:
A novel enantioselective palladium-catalyzed dearomative cyclization has been developed for the efficient construction of a series of chiral phenanthrenone derivatives bearing an all-carbon quaternary center.
CONCLUSIONS:
The effectiveness of this method in the synthesis of terpenes and steroids was demonstrated by a highly efficient synthesis of a kaurene intermediate, the facile construction of the skeleton of the anabolic steroid boldenone, and the enantioselective total synthesis of the antimicrobial diterpene natural product (-)-Totaradiol.
CFN97733Totarol511-15-9286.46C20H30O
CFN98610Totaradiol3772-56-3302.5 C20H30O2
CFN961674beta-Carboxy-19-nortotarol55102-39-1316.4C20H28O3
CFN96140Nagilactone C24338-53-2362.4C19H22O7
CFN96150Nagilactone B19891-51-1364.4C19H24O7
CFN89100Hispidanin B1616080-84-2656.89C42H56O6
Featured Products
Corosolic acid

Catalog No: CFN98685
CAS No: 4547-24-4
Price: $60/20mg
Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg
Senkyunolide I

Catalog No: CFN99596
CAS No: 94596-28-8
Price: $100/20mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Isovitexin-2''-O-rhamnoside (2''-O...

Catalog No: CFN95314
CAS No: 72036-50-1
Price: $318/5mg
L-Citruline

Catalog No: CFN90551
CAS No: 372-75-8
Price: $30/20mg
3,7-Di-O-methylquercetin

Catalog No: CFN96221
CAS No: 2068-02-2
Price: $/mg
Stevenleaf

Catalog No: CFN99189
CAS No: 80321-63-7
Price: $ / mg
Ganoderic acid B

Catalog No: CFN92052
CAS No: 81907-61-1
Price: $288/20mg
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
Tags: buy Totaradiol | Totaradiol supplier | purchase Totaradiol | Totaradiol cost | Totaradiol manufacturer | order Totaradiol | Totaradiol distributor
1 Building, No. 176, CheCheng East Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Copyright© 2011-2023 | ChemFaces all rights reserved | Tel: +86-27-84237683
E-mail:manager@chemfaces.com
payment