Vallesiachotamine | CAS:5523-37-5 | Manufacturer ChemFaces

Vallesiachotamine

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Description:

Vallesiachotamine exhibits important cytotoxicity toward human melanoma cells by apoptosis and necrosis.

In vitro:

Arch Pharm Res. 2012 Mar;35(3):565-71.

In vitro antiproliferative effects of the indole alkaloid vallesiachotamine on human melanoma cells.[Pubmed: 22477204]

Vallesiachotamine was isolated from the leaves of Palicourea rigida (Rubiaceae) collected in the Brazilian Cerrado.
METHODS AND RESULTS:
The structure was determined by spectroscopic methods, mainly 1D- and 2D-NMR and its biological activities were investigated on cultured human (SK-MEL-37) melanoma cells. In vitro cytotoxicity was evaluated by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The inhibitory concentration (IC(50)) was 14.7 ± 1.2 μM for 24 h of drug exposure. Flow cytometry analysis revealed that Vallesiachotamine induced G0/G1 arrest and increased the proportion of sub-G1 hypodiploid cells (at 11 μM and 22 μM) and this effect was not dependent on time of incubation. At these concentrations, a typical ladder was observed by agarose gel electrophoresis of the extracted DNA. Treatment of cells with 50 μM Vallesiachotamine for 24 h caused extensive cytotoxicity and necrosis.
CONCLUSIONS:
Our results demonstrated that the indole alkaloid Vallesiachotamine exhibited important cytotoxicity toward human melanoma cells and that apoptosis and necrosis might be responsible for the observed events.

Vallesiachotamine Description

Source:	The herbs of Uncaria rhynchophylla
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vallesiachotamine
Price:
CAS No.:	5523-37-5
Catalog No.:	CFN92640
Molecular Formula:	C₂₁H₂₂N₂O₃
Molecular Weight:	350.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Uncaria rhynchophylla
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Pro-apoptotic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8539 mL	14.2694 mL	28.5388 mL	57.0776 mL	71.347 mL
5 mM	0.5708 mL	2.8539 mL	5.7078 mL	11.4155 mL	14.2694 mL
10 mM	0.2854 mL	1.4269 mL	2.8539 mL	5.7078 mL	7.1347 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	1.1416 mL	1.4269 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	0.5708 mL	0.7135 mL

CFN80224	3alpha-dihydrocadambine	54483-84-0	546.22	C₂₇H₃₄N₂O₁₀
CFN92640	Vallesiachotamine	5523-37-5	350.4	C₂₁H₂₂N₂O₃
CFN92641	Isovallesiachotamine	34384-71-9	350.4	C₂₁H₂₂N₂O₃
CFN96096	(16R)-E-Isositsirikine	6519-27-3	354.5	C₂₁H₂₆N₂O₃
CFN95566	Geissoschizine	439-66-7	368.4	C₂₁H₂₄N₂O₄
CFN89459	Geissoschizine methyl ether	60314-89-8	366.45	C₂₂H₂₆N₂O₃
CFN96218	Sitsirikine	1245-00-7	354.5	C₂₁H₂₆N₂O₃
CFN90615	Hirsuteine	35467-43-7	366.45	C₂₂H₂₆N₂O₃
CFN90617	Hirsutine	7729-23-9	368.47	C₂₂H₂₈N₂O₃
CFN97115	(16R)-Dihydrositsirikine	6519-26-2	356.5	C₂₁H₂₈N₂O₃