Vermisporin | CAS:122301-98-8 | Manufacturer ChemFaces

Vermisporin

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Description:

Vermisporin, a new antibiotic produced by fermentation of the fungus ophiobolus vermisporis. Vermisporin has antimicrobial activity, which MICs for enterobacteriaceae, pseudomonas aeruginosa and haemophilus influenzae exceeds 64 micrograms/ml; which MBCs is 16- to 32-fold above the MICs.

Targets:

Antifection

In vitro:

Eur J Clin Microbiol Infect Dis. 1992 Aug;11(8):755-7.

In vitro antimicrobial activity of the new antibiotic vermisporin.[Pubmed: 1425739]

The antimicrobial activity of Vermisporin, a new antibiotic produced by fermentation of the fungus Ophiobolus vermisporis, was tested in vitro.
METHODS AND RESULTS:
Vermisporin inhibited 90% of Bacteroides fragilis and other Bacteroides spp. at 1 microgram/ml (range 0.25-1 micrograms/ml). Clostridium perfringens were inhibited by 1 microgram/ml (range 0.25-2 micrograms/ml). Vermisporin inhibited 90% of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, at 0.5 micrograms/ml (range 0.12-0.5 micrograms/ml).
CONCLUSIONS:
Vermisporin MICs for group A, B, C, F and G streptococci were < 1 microgram/ml when tested in Haemophilus Test Medium but > or = 8 micrograms/ml in the presence of blood. Vermisporin MICs for Enterobacteriaceae, Pseudomonas aeruginosa and Haemophilus influenzae exceeded 64 micrograms/ml. Inhibited organisms had MBCs 16- to 32-fold above the MICs.

Vermisporin Description

Source:	From the fermentation of the fungus Ophiobolus vermisporis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J Antibiot (Tokyo). 2005 May;58(5):338-45.

Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840.[Pubmed: 16060386]

METHODS AND RESULTS:
During our screening for microbial inhibitors of lipid droplet accumulation in macrophages, a new compound designated spylidone was isolated along with two structurally related known compounds, PF1052 and Vermisporin, from the fermentation broth of Phoma sp. FKI-1840 by solvent extraction, silica gel column chromatography, ODS column chromatography and preparative HPLC. From the structure elucidation, spylidone has a spiro ring containing 2,4-pyrrolidinedione.
CONCLUSIONS:
Among the three compounds, only spylidone was found to inhibit lipid droplet accumulation in macrophages at 10 to approximately 50 microM without any cytotoxic effect.

Product Name	Vermisporin
Price:
CAS No.:	122301-98-8
Catalog No.:	CFN00143
Molecular Formula:	C₂₅H₃₇NO₄
Molecular Weight:	415.57 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	From the fermentation of the fungus Ophiobolus vermisporis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4063 mL	12.0317 mL	24.0633 mL	48.1267 mL	60.1583 mL
5 mM	0.4813 mL	2.4063 mL	4.8127 mL	9.6253 mL	12.0317 mL
10 mM	0.2406 mL	1.2032 mL	2.4063 mL	4.8127 mL	6.0158 mL
50 mM	0.0481 mL	0.2406 mL	0.4813 mL	0.9625 mL	1.2032 mL
100 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.4813 mL	0.6016 mL

CFN00105	Antibiotic 2158	182320-34-9	519.72	C₃₃H₄₅NO₄
CFN00106	Antibiotic AB 4015B	162857-79-6	413.6	C₂₆H₃₉NO₃
CFN00107	Antibiotic AB 4063B	160041-33-8	413.6	C₂₆H₃₉NO₃
CFN00108	Antibiotic PF 1052	147317-15-5	429.60	C₂₆H₃₉NO₄
CFN00113	Delaminomycin A	149779-38-4	501.66	C₂₉H₄₃NO₆
CFN00115	Equisetin	57749-43-6	373.49	C₂₂H₃₁NO₄
CFN00129	Oteromycin	170591-45-4	487.68	C₃₂H₄₁NO₃
CFN00130	Antibiotic ZG 1494alpha	182320-33-8	505.70	C₃₂H₄₃NO₄
CFN00143	Vermisporin	122301-98-8	415.57	C₂₅H₃₇NO₄
CFN00145	Zopfiellamide A	478945-64-1	445.55	C₂₅H₃₅NO₆