Vibralactone B | CAS:1093230-95-5 | Manufacturer ChemFaces

Vibralactone B

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Description:

Vibralactone B shows antibacterial activity, it can inhibit significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 ug/mL, respectively.

Targets:

Antifection

In vitro:

Food Chem Toxicol. 2017 May 18. pii: S0278-6915(17)30264-8.

Antifungal activities of secondary metabolites isolated from liquid fermentations of Stereum hirsutum (Sh134-11) against Botrytis cinerea (grey mould agent).[Pubmed: 28528973]

METHODS AND RESULTS:
Extracts obtained from liquid mycelial fermentations of the Chilean fungus Stereum hirsutum (Sh134-11) showed antifungal activity against Botrytis cinerea. Two types of extracts were obtained: EtOAc-extract (liquid phase) and MeOH-extract (mycelial phase). Plate diffusion assay showed that EtOAc-extracts were more active than MeOH-extracts. A large-scale fermentation of Sh134-11 and chromatographic methods allowed to isolated four compounds: MS-3, Vibralactone, Vibralactone B and Sterenin D. Only Sterenin D showed antifungal activity against B. cinerea in the tests performed. Effects on the mycelial growth of B. cinerea showed that Sterenin D showed inhibition at 1000-2000 μg/mL reaching 67% and 76% respectively. Sterenin D was more effective to control the sporogenesis, inhibiting in 96% the sporulation at 500 μg/mL. Assays showed that Sterenin D exhibited a minimal fungicidal concentration (MFC) of 50 μg/mL and minimal inhibitory concentration (MIC) at 20 μg/mL.
CONCLUSIONS:
Our study indicated that submerged fermentations of Chilean S. hirsutum (Sh134-11) produced extracts with antifungal activity and Sterenin D is responsible for this activity, which could be used as possible biofungicides alternative to synthetic fungicides.

Z Naturforsch C. 2015;70(3-4):97-102.

Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale.[Pubmed: 26020559 ]

METHODS AND RESULTS:
Liquid fermentations of the fungus Stereum rameale (N° 2511) yielded extracts with antibacterial activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and Vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration.
CONCLUSIONS:
Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 μg/mL), Bacillus subtilis (10 μg/mL) and Staphylococcus aureus (100 μg/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 μg/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 μg/mL, respectively.

Vibralactone B Description

Source:	From the cultures of the Basidiomycete Boreostereum vibrans.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vibralactone B
Price:
CAS No.:	1093230-95-5
Catalog No.:	CFN96455
Molecular Formula:	C₁₂H₁₆O₄
Molecular Weight:	224.26 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	From the cultures of the Basidiomycete Boreostereum vibrans.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Sesquiterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4591 mL	22.2955 mL	44.5911 mL	89.1822 mL	111.4777 mL
5 mM	0.8918 mL	4.4591 mL	8.9182 mL	17.8364 mL	22.2955 mL
10 mM	0.4459 mL	2.2296 mL	4.4591 mL	8.9182 mL	11.1478 mL
50 mM	0.0892 mL	0.4459 mL	0.8918 mL	1.7836 mL	2.2296 mL
100 mM	0.0446 mL	0.223 mL	0.4459 mL	0.8918 mL	1.1148 mL

CFN89015	Bisacurone C	127214-86-2	252.35	C₁₅H₂₄O₃
CFN89024	3-Hydroxybisabola-1,10-dien-9-one	129673-86-5	236.35	C₁₅H₂₄O₂
CFN89025	3,4-Dihydroxybisabola-1,10-diene	129673-87-6	238.37	C₁₅H₂₆O₂
CFN89249	1,4-Epidioxybisabola-2,10-dien-9-one	170380-69-5	250.33	C₁₅H₂₂O₃
CFN89224	Bisabola-3,10-dien-2-one	61432-71-1	220.35	C₁₅H₂₄O
CFN96995	1-Hydroxybisabola-2,10-dien-4-one	1213251-45-6	236.35	C₁₅H₂₄O₂
CFN89244	4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one	170380-68-4	220.31	C₁₄H₂₀O₂
CFN97512	9-Oxo-2,7-bisaboladien-15-oic acid	93888-59-6	250.3	C₁₅H₂₂O₃
CFN96371	4-Hydroxy-1,10-secocadin-5-ene-1,10-dione	226904-40-1	252.4	C₁₅H₂₄O₃
CFN91876	Bisabolangelone	30557-81-4	248.32	C₁₅H₂₀O₃