Viroallosecurinine | CAS:1857-30-3 | Manufacturer ChemFaces

Viroallosecurinine

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Description:

Virosecurinine and viroallosecurinine were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. Viroallosecurinine exhibits a MIC of 0.48 micrograms/ml for Pseudomonas aeruginosa and Staphylococcus aureus.

Targets:

Antifection

In vitro:

Nat Prod Res. 2007 Mar;21(3):234-42.

Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids.[Pubmed: 17365714 ]

Investigations on callus cultures of Securinega suffruticosa indicated that the cell line of S. suffruticosa callus was able to accumulate four known Securinega alkaloids with dextro rotation but not levo rotation as reported before: virosecurinine (1), Viroallosecurinine (2), 14,15-dihydrovirosecurinine (3) and ent-phyllanthidine (4). Time course studies on the growth of callus cultures were carried out. The effects of different plant growth regulators, sucrose concentrations on callus growth and virosecurinine production were also reported.

J Ethnopharmacol. 1990 Feb;28(1):129-33.

Antibacterial activity of the leaves of Phyllanthus discoideus.[Pubmed: 2156112]

The lyophilized aqueous extract (LWE) from the leaves of Phyllanthus discoideus was found to show an antibacterial activity.
METHODS AND RESULTS:
The alkaloid fraction obtained from LWE inhibited the growth of Escherichia coli and Enterococcus faecium (MIC = 1.6 mg/ml), Pseudomonas aeruginosa (MIC = 0.78 mg/ml), Staphylococcus aureus and Mycobacterium smegmatis (MIC = 0.2 mg/ml). Among the alkaloids identified, Viroallosecurinine and securinine showed a high activity. Viroallosecurinine exhibited a MIC of 0.48 micrograms/ml for Ps. aeruginosa and Staph. aureus.
CONCLUSIONS:
This alkaloid is bactericidal since the yields of MIC/MBC were less than 1. The MIC of securinine was 0.500 mg/ml for E. coli, Staph. aureus and Myc. smegmatis. These effects of Phyllanthus discoideus leaf extracts support some of the local uses of the plant in traditional therapy.

Viroallosecurinine Description

Source:	The roots of Securinega virosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Viroallosecurinine
Price:	$318 / 5mg
CAS No.:	1857-30-3
Catalog No.:	CFN96450
Molecular Formula:	C₁₃H₁₅NO₂
Molecular Weight:	217.27 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Securinega virosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Cytotoxic Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.6026 mL	23.0128 mL	46.0257 mL	92.0514 mL	115.0642 mL
5 mM	0.9205 mL	4.6026 mL	9.2051 mL	18.4103 mL	23.0128 mL
10 mM	0.4603 mL	2.3013 mL	4.6026 mL	9.2051 mL	11.5064 mL
50 mM	0.0921 mL	0.4603 mL	0.9205 mL	1.841 mL	2.3013 mL
100 mM	0.046 mL	0.2301 mL	0.4603 mL	0.9205 mL	1.1506 mL

CFN96777	Daphnicyclidin D	385384-24-7	381.47	C₂₃H₂₇NO₄
CFN96778	Daphnicyclidin F	385384-26-9	397.47	C₂₃H₂₇NO₅
CFN97448	Daphniyunnine B	881388-88-1	343.5	C₂₁H₂₉NO₃
CFN96776	Daphnicyclidin H	385384-29-2	399.48	C₂₃H₂₉NO₅
CFN96733	Daphnicyclidin I	1467083-10-8	366.46	C₂₂H₂₆N₂O₃
CFN96737	Hybridaphniphylline A	1467083-07-3	681.77	C₃₇H₄₇NO₁₁
CFN96740	Hybridaphniphylline B	1467083-09-5	681.77	C₃₇H₄₇NO₁₁
CFN96449	Virosine B	1052228-70-2	235.28	C₁₃H₁₇NO₃
CFN96679	Securinol A	5008-48-0	235.28	C₁₃H₁₇NO₃
CFN96450	Viroallosecurinine	1857-30-3	217.27	C₁₃H₁₅NO₂