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Wilforol A
Wilforol A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Wilforol A
Price:
CAS No.: 167882-66-8
Catalog No.: CFN92083
Molecular Formula: C29H38O5
Molecular Weight: 466.6 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Tripterygium wilfordii Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Wilforol A is a natural product from Tripterygium wilfordii Hook. f.
Wilforol A Description
Source: The herbs of Tripterygium wilfordii Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1432 mL 10.7158 mL 21.4316 mL 42.8633 mL 53.5791 mL
5 mM 0.4286 mL 2.1432 mL 4.2863 mL 8.5727 mL 10.7158 mL
10 mM 0.2143 mL 1.0716 mL 2.1432 mL 4.2863 mL 5.3579 mL
50 mM 0.0429 mL 0.2143 mL 0.4286 mL 0.8573 mL 1.0716 mL
100 mM 0.0214 mL 0.1072 mL 0.2143 mL 0.4286 mL 0.5358 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Am Chem Soc. 2015 Sep 23;137(37):11864-7.
Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products.[Pubmed: 26331410 ]
Celastroid natural products, triterpenes, have been and continue to be investigated in clinical trials.
METHODS AND RESULTS:
Celastrol, and for that matter any member of the celastroid family, was prepared for the first time through chemical synthesis starting from 2,3-dimethylbutadiene. A triene cyclization precursor generated in 12 steps underwent a nonbiomimetic polyene cyclization mediated by ferric chloride to generate the generic celastroid pentacyclic core.
CONCLUSIONS:
In the cyclization, engagement of a tetrasubstituted olefin formed adjacent all carbon quaternary centers stereospecifically. With access to the carbocyclic core of the family of natural products, wilforic acid and Wilforol A were prepared en route to racemic celastrol.
CFN92084Zeylasteral87064-16-2494.6C30H38O6
CFN91915Zeylasterone78012-25-6510.62C30H38O7
CFN91916Blepharotriol849590-42-7482.61C29H38O6
CFN96477Triptocalline A201534-10-3442.64C28H42O4
CFN919186-Oxo-23-norpristimerol118172-79-5466.61C29H38O5
CFN92083Wilforol A167882-66-8466.6C29H38O5
CFN92571Triptotin F359630-36-7496.7C31H44O5
CFN91639Populninic acid120090-56-4470.69C30H46O4
CFN90169Pristimerin1258-84-0464.64C30H40O4
CFN99198Celastrol34157-83-0450.61C29H38O4
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