Xanthohumol B | CAS:189308-10-9 | Manufacturer ChemFaces

Xanthohumol B

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Description:

Reference standards.

In vitro:

Phytochemistry. 1997 Oct;46(4):683-7.

Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.[Pubmed: 9366096]

A methanol extract of hops of Humulus lupulus (L.) showed inhibitory activity against rat liver diacylglycerol acyltransferase (DGAT).
METHODS AND RESULTS:
From DGAT inhibitory activity-guided fractionation, two chalcones were isolated. One was identified as xanthohumol and the other was found to be a new product designated Xanthohumol B. The structure of Xanthohumol B was shown to be 6-[3,4-dihydro-3,5-dihydroxy-7-methoxy-2,2-dimethyl-2H-benzo[b]pyrano ]- 3-(4-hydroxyphynyl)-2-propen-l-one by spectroscopic studies including various NMR measurements. Xanthohumol and Xanthohumol B inhibited DGAT activity with IC50 values of 50.3 and 194 microM in rat liver microsomes, respectively.
CONCLUSIONS:
They showed preferential inhibition of triacylglycerol formation in intact Raji cells, indicating that they inhibit DGAT activity preferentially in living cells.

Xanthohumol B Description

Source:	The herbs of Humulus lupulus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Xanthohumol B
Price:
CAS No.:	189308-10-9
Catalog No.:	CFN91956
Molecular Formula:	C₂₁H₂₂O₆
Molecular Weight:	370.40 g/mol
Purity:	>=98%
Type of Compound:	Chalcones
Physical Desc.:	Powder
Source:	The herbs of Humulus lupulus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Chalcones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6998 mL	13.4989 mL	26.9978 mL	53.9957 mL	67.4946 mL
5 mM	0.54 mL	2.6998 mL	5.3996 mL	10.7991 mL	13.4989 mL
10 mM	0.27 mL	1.3499 mL	2.6998 mL	5.3996 mL	6.7495 mL
50 mM	0.054 mL	0.27 mL	0.54 mL	1.0799 mL	1.3499 mL
100 mM	0.027 mL	0.135 mL	0.27 mL	0.54 mL	0.6749 mL

CFN92219	Bavachromene	41743-38-8	322.4	C₂₀H₁₈O₄
CFN92220	Isobavachromene	52801-22-6	322.4	C₂₀H₁₈O₄
CFN91509	Xanthohumol C	189299-05-6	352.4	C₂₁H₂₀O₅
CFN96193	Dorsmanin A	162229-27-8	324.4	C₂₀H₂₀O₄
CFN91956	Xanthohumol B	189308-10-9	370.40	C₂₁H₂₂O₆
CFN91958	Xanthohumol I	688360-06-7	370.40	C₂₁H₂₂O₆
CFN91957	Xanthohumol L	688360-15-8	370.40	C₂₁H₂₂O₆
CFN96199	Isodorsmanin A	118266-99-2	324.4	C₂₀H₂₀O₄
CFN92229	Bakuchalcone	84575-13-3	340.4	C₂₀H₂₀O₅
CFN92230	Brosimacutin G	350221-50-0	356.4	C₂₀H₂₀O₆