alpha-Amyrin | CAS:638-95-9 | Manufacturer ChemFaces

alpha-Amyrin

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Description:

Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory potent to feasibility for a promising liver curative drug.

Targets:

ROS | P450 (e.g. CYP17)

In vitro:

Acta Biochim Pol. 2012;59(2):255-60.

Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage.[Pubmed: 22577623]

Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, alpha-Amyrin, in methanol extract from leaves of this plant.
METHODS AND RESULTS:
alpha-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of alpha-Amyrin indicated no antioxidative activity of this compound.
CONCLUSIONS:
alpha-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.

In vivo:

J Ethnopharmacol. 2015 Feb 23;161:186-93.

Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats.[Pubmed: 25542388]

alpha-Amyrin (a pentacyclic triterpene widely distributed in nature and isolated from a variety of plant sources and pharmacologically shown a wide spectrum of activity including anti-inflammatory, anti-ulcer, anti-hyperlipidemic, anti-tumor, and hepatoprotective actions) explored as hepatomodulator from the ethanol extract of the stem bark of Alstonia scholaris Linn.
METHODS AND RESULTS:
Experimental rats, hepato-oxidatively stressed by CCl4 (0.2 ml/kg b wt/twice a week, intra-peritoneally), were concurrently received alpha-Amyrin (20mg/kg body weight/day, orally) for 30 consecutive days. The assessment of all biochemical parameters registered a significant (P<0.001) hepatic oxidative stress in CCl4 treated rats, which was considerably recovered near to almost normal level in rats co-administered with alpha-Amyrin at the dose level of 20mg/kg body weight/day for 30 consecutive days. The histoarchitectural examination of liver sections from treated groups further corroborated the hepatomodulatory potential of alpha-Amyrin and compared with standard drug-silymarin.
CONCLUSIONS:
These findings indicate that the modulatory potential of alpha-Amyrin against hepatic oxidative stress possibly involve mechanism related to its ability to block the P-450 mediated CCl4 bioactivation through selective inhibitors of ROS (reactive oxygen species) as antioxidants brought about significant inhibition of the formation of LPO suggesting possible involvement of O2(●-), HO2, HO2(●-), H2O2 and •OH. Therefore this study suggests that the use of alpha-Amyrin as a hepatomodulatory potent to feasibility for a promising liver curative drug.

alpha-Amyrin Description

Source:	The herbs of Artemisia vulgaris
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	alpha-Amyrin
Price:	$318 / 5mg
CAS No.:	638-95-9
Catalog No.:	CFN92377
Molecular Formula:	C₃₀H₅₀O
Molecular Weight:	426.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Artemisia vulgaris
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Analgesia Compound Library Anti-diabetic complications Compound Library Triterpenoids Compound Library ROS Inhibitor Library P450 (e.g. CYP17) Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3436 mL	11.7178 mL	23.4357 mL	46.8713 mL	58.5892 mL
5 mM	0.4687 mL	2.3436 mL	4.6871 mL	9.3743 mL	11.7178 mL
10 mM	0.2344 mL	1.1718 mL	2.3436 mL	4.6871 mL	5.8589 mL
50 mM	0.0469 mL	0.2344 mL	0.4687 mL	0.9374 mL	1.1718 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	0.4687 mL	0.5859 mL

CFN97423	alpha-Amyrin acetate	863-76-3	468.8	C₃₂H₅₂O₂
CFN98210	alpha-Amyrin palmitate	22255-10-3	665.1	C₄₆H₈₀O₂
CFN98689	Pseudotaraxasterol	464-98-2	426.7	C₃₀H₅₀O
CFN93020	Faradiol	20554-95-4	442.7	C₃₀H₅₀O₂
CFN99074	Taraxasterol	1059-14-9	426.7	C₃₀H₅₀O
CFN97104	Taraxasterol acetate	6426-43-3	468.8	C₃₂H₅₂O₂
CFN89469	Taraxasterone	6786-16-9	424.70	C₃₀H₄₈O
CFN93111	Arnidiol	6750-30-7	440.7	C₃₀H₄₈O₂
CFN99808	Bauerenol acetate	17020-04-1	468.8	C₃₂H₅₂O₂
CFN98912	Uvaol	545-46-0	442.7	C₃₀H₅₀O₂