bis[6-(5,6-dihydrochelerythrinyl)]amine | CAS:165393-48-6

bis[6-(5,6-dihydrochelerythrinyl)]amine

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Description:

BIS-[6-(5,6-dihydro-chelerythrinyl)] ether shows strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA).

Targets:

Antifection

In vitro:

Planta Med. 2011 Sep;77(13):1542-4.

Chemical constituents, antimicrobial and antimalarial activities of Zanthoxylum monophyllum.[Pubmed: 21341176]

METHODS AND RESULTS:
From the leaves and bark of Zanthoxylum monophyllum, a new lignan, 3-methoxy-3',4'-methylenedioxylignan-4,8,9,9'-tetraol (1), has been isolated along with 22 known compounds (2- 23), fifteen of them reported for the first time from Z. monophyllum. Their chemical structures were elucidated using detailed spectroscopic studies and chemical analysis. All compounds were evaluated for antimicrobial and antiprotozoal activities.
CONCLUSIONS:
Alkaloids BIS-[6-(5,6-dihydro-chelerythrinyl)] ether (2) and 6-ethoxy-chelerythrine (4) exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 4-methoxy-N-methyl-2-quinolone (9) exhibited significant activity against MRSA (IC50 value of 8.0 μM) while compound 5,8,4'-trihydroxy-3,7,3'-trimethoxyflavone (10) showed weak activity against Plasmodium falciparum.

bis[6-(5,6-dihydrochelerythrinyl)]amine Description

Source:	The herbs of Macleaya cordata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	bis[6-(5,6-dihydrochelerythrinyl)]amine
Price:
CAS No.:	165393-48-6
Catalog No.:	CFN91015
Molecular Formula:	C₄₂H₃₇N₃O₈
Molecular Weight:	711.76 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Macleaya cordata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.405 mL	7.0248 mL	14.0497 mL	28.0994 mL	35.1242 mL
5 mM	0.281 mL	1.405 mL	2.8099 mL	5.6199 mL	7.0248 mL
10 mM	0.1405 mL	0.7025 mL	1.405 mL	2.8099 mL	3.5124 mL
50 mM	0.0281 mL	0.1405 mL	0.281 mL	0.562 mL	0.7025 mL
100 mM	0.014 mL	0.0702 mL	0.1405 mL	0.281 mL	0.3512 mL

CFN95373	Bocconoline	32906-88-0	379.4	C₂₂H₂₁NO₅
CFN99367	6-Acetonyl-N-methyl-dihydrodecarine	1253740-09-8	391.4	C₂₃H₂₁NO₅
CFN98233	6-Acetonyldihydrochelerythrine	22864-92-2	405.5	C₂₄H₂₃NO₅
CFN98608	8-Acetonyldihydrosanguinarine	37687-34-6	389.4	C₂₃H₁₉NO₅
CFN92338	8-Acetonyldihydroavicine	348098-59-9	389.4	C₂₃H₁₉NO₅
CFN92339	8-Acetonyldihydronitidine	80330-39-8	405.5	C₂₄H₂₃NO₅
CFN91015	bis[6-(5,6-dihydrochelerythrinyl)]amine	165393-48-6	711.76	C₄₂H₃₇N₃O₈
CFN99749	Acetylcorynoline	18797-80-3	409.43	C₂₃H₂₃NO₆
CFN90319	Chelidonine	476-32-4	353.37	C₂₀H₁₉NO₅
CFN90127	Dihydrochelerythrine	6880-91-7	349.38	C₂₁H₁₉NO₄