Science | Nature | Cell | View More
Natural Products
ent-17-Hydroxykaur-15-en-19-oic acid
ent-17-Hydroxykaur-15-en-19-oic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name ent-17-Hydroxykaur-15-en-19-oic acid
Price:
CAS No.: 35030-38-7
Catalog No.: CFN97752
Molecular Formula: C20H30O3
Molecular Weight: 318.46 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Wedelia trilobata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Hamdard University (India)
  • Sanford Burnham Medical Researc... (USA)
  • Georgia Institute of Technology (USA)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • Utah State University (USA)
  • University of Vigo (Spain)
  • University of Dicle (Turkey)
  • Universite de Lille1 (France)
  • Centralised Purchases Unit (CPU... (India)
  • Center for protein Engineering ... (Belgium)
  • Donald Danforth Plant Science C... (USA)
  • More...
Package
Featured Products
Irisflorentin

Catalog No: CFN99788
CAS No: 41743-73-1
Price: $40/20mg
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Harpagide

Catalog No: CFN98148
CAS No: 6926-08-5
Price: $70/20mg
Vincristine

Catalog No: CFN98589
CAS No: 57-22-7
Price: $138/20mg
Decursinol

Catalog No: CFN90496
CAS No: 23458-02-8
Price: $238/20mg
Riboflavine

Catalog No: CFN90067
CAS No: 83-88-5
Price: $30/20mg
Noroxyhydrastinine

Catalog No: CFN90504
CAS No: 21796-14-5
Price: $318/5mg
Betulinic acid

Catalog No: CFN98706
CAS No: 472-15-1
Price: $40/20mg
Biatractylolide

Catalog No: CFN95205
CAS No: 182426-37-5
Price: $268/10mg
Ganoderic acid TR

Catalog No: CFN92235
CAS No: 862893-75-2
Price: $368/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: ent-17-Hydroxykaur-15-en-19-oic acid shows cytotoxicity against human prostate (22Rv1, LNCaP), colon (HT29, HCT116, SW480, SW620), and breast (MCF-7) tumor cells at concentrations ranging from 6 to 50microg/mL.
In vitro:
Cancer Lett. 2006 Dec 8;244(2):190-4.
Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro.[Pubmed: 16448743 ]

METHODS AND RESULTS:
Four ent-kaurene diterpenes were isolated from the leaves of Laetia thamnia L.: ent-kaur-16-en-19-oic acid (1a), ent-3beta-hydroxykaur-16-ene (2), ent-kaur-16-en-3alpha,19-diol (3a), and ent-17-Hydroxykaur-15-en-19-oic acid (4). The methyl ester (1b) of compound 1a and the acetate diester (3b) of compound 3a were prepared, and all compounds were evaluated for cytotoxicity against human prostate (22Rv1, LNCaP), colon (HT29, HCT116, SW480, SW620), and breast (MCF-7) tumor cells at concentrations ranging from 6 to 50microg/mL.
CONCLUSIONS:
The kaurenes showed activity in all cell lines tested, with the prostate cells demonstrating the most sensitivity as follows: 22 Rv1 cells towards 1a (IC(50) 5.03microg/mL) and 1b (IC(50) 6.81microg/mL), and LNCaP towards 2 (IC(50) 12.83microg/mL) and 4 (IC(50) 17.63microg/mL).
Ultrason Sonochem. 2014 Jul;21(4):1578-84.
Bio-guided optimization of the ultrasound-assisted extraction of compounds from Annona glabra L. leaves using the etiolated wheat coleoptile bioassay.[Pubmed: 24556321 ]
A bio-guided optimization of the extraction of bioactive components from Annona glabra leaves has been developed using the etiolated wheat coleoptile bioassay as the control method.
METHODS AND RESULTS:
The optimization of an ultrasound-assisted extraction of bioactive compounds using allelopathy results as target values has been carried out for the first time. A two-level fractional factorial experimental design was applied to optimize the ultrasound-assisted extraction. The solvent was the extraction variable that had the most marked effect on the resulting bioactivity of the extracts in the etiolated wheat coleoptile bioassay. Extraction time, extraction temperature and the size of the ultrasonic probe also influenced the bioactivity of the extracts. A larger scale extraction was carried out in the next step in the allelopathic study, i.e., the isolation of compounds from the bioactive extract and chemical characterization by spectroscopic techniques, including NMR. Eight compounds were isolated and identified from the active extracts, namely two steroids (β-sistosterol and stigmasterol), five diterpenes with the kaurane skeleton (ent-kaur-16-en-19-oic acid, ent-19-methoxy-19-oxokauran-17-oic acid, annoglabasin B, ent-17-Hydroxykaur-15-en-19-oic acid and ent-15β,16β-epoxy-17-hydroxy-kauran-19-oic acid) and the acetogenin asimicin.
CONCLUSIONS:
The most active compound was annoglabasin B, which showed inhibition with values of -95% at 10(-3) M, -87% at 5×10(-4) M and greater than -70% at 10(-4) M in the etiolated wheat coleoptile bioassay.
ent-17-Hydroxykaur-15-en-19-oic acid Description
Source: The herbs of Wedelia trilobata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3-Acetyl-ginsenoside F1

Catalog No: CFN95238
CAS No: 1881225-08-6
Price: $318/5mg
Polygalin C

Catalog No: CFN95118
CAS No: 934768-05-5
Price: $288/5mg
Narirutin 4'-glucoside

Catalog No: CFN95421
CAS No: 17257-22-6
Price: $318/10mg
1-Isomangostin

Catalog No: CFN95114
CAS No: 19275-44-6
Price: $318/5mg
Genistein 7-O-beta-D-glucopyranosi...

Catalog No: CFN95159
CAS No: 70404-42-1
Price: $318/10mg
3-Hydroxymollugin

Catalog No: CFN95424
CAS No: 154706-45-3
Price: $368/5mg
Menisperine

Catalog No: CFN95318
CAS No: 25342-82-9
Price: $318/10mg
11alpha-hydroxy-3,7-dioxo-5alpha-l...

Catalog No: CFN95592
CAS No: 1245703-70-1
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1401 mL 15.7006 mL 31.4011 mL 62.8022 mL 78.5028 mL
5 mM 0.628 mL 3.1401 mL 6.2802 mL 12.5604 mL 15.7006 mL
10 mM 0.314 mL 1.5701 mL 3.1401 mL 6.2802 mL 7.8503 mL
50 mM 0.0628 mL 0.314 mL 0.628 mL 1.256 mL 1.5701 mL
100 mM 0.0314 mL 0.157 mL 0.314 mL 0.628 mL 0.785 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry.1993 Dec;34(6):1483–1487.
Occurrence and origin of ent-17-hydroxykaur-15-ene and ent-17-hydroxykaur-15-en-19-oic acid in shoots of Zea mays.[Reference: WebLink]
Previously unidentified metabolites of ent-kaur-16-ene and ent-kaur-16-en-19-oic acid in shoots of maize are identified, respectively, as ent-17-hydroxykaur-15-ene and ent-17-Hydroxykaur-15-en-19-oic acid by GC-MS comparison with authentic samples.
METHODS AND RESULTS:
The production of the two latter compounds from the first two substances is analogous to the metabolism of gibberellin A5 to gibberellin A3 and provides two further examples, in plants, of hydroxylation at a double bond with rearrangement of the double bond.
Irisflorentin

Catalog No: CFN99788
CAS No: 41743-73-1
Price: $40/20mg
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Harpagide

Catalog No: CFN98148
CAS No: 6926-08-5
Price: $70/20mg
Vincristine

Catalog No: CFN98589
CAS No: 57-22-7
Price: $138/20mg
Decursinol

Catalog No: CFN90496
CAS No: 23458-02-8
Price: $238/20mg
Riboflavine

Catalog No: CFN90067
CAS No: 83-88-5
Price: $30/20mg
Noroxyhydrastinine

Catalog No: CFN90504
CAS No: 21796-14-5
Price: $318/5mg
Betulinic acid

Catalog No: CFN98706
CAS No: 472-15-1
Price: $40/20mg
Biatractylolide

Catalog No: CFN95205
CAS No: 182426-37-5
Price: $268/10mg
Ganoderic acid TR

Catalog No: CFN92235
CAS No: 862893-75-2
Price: $368/5mg
Tags: buy ent-17-Hydroxykaur-15-en-19-oic acid | ent-17-Hydroxykaur-15-en-19-oic acid supplier | purchase ent-17-Hydroxykaur-15-en-19-oic acid | ent-17-Hydroxykaur-15-en-19-oic acid cost | ent-17-Hydroxykaur-15-en-19-oic acid manufacturer | order ent-17-Hydroxykaur-15-en-19-oic acid | ent-17-Hydroxykaur-15-en-19-oic acid distributor