Science | Nature | Cell | View More
Natural Products
gamma-Fagarine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name gamma-Fagarine
Price: $288 / 5mg
CAS No.: 524-15-2
Catalog No.: CFN98858
Molecular Formula: C13H11NO3
Molecular Weight: 229.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The fruits of Zanthoxylum simulans Hance
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $152.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Northeast Normal University Cha... (China)
  • The Vancouver Prostate Centre (... (Canada)
  • University of Indonesia (Indonesia)
  • Ain Shams University (Egypt)
  • University of Zurich (Switzerland)
  • University of East Anglia (United Kingdom)
  • Aveiro University (Portugal)
  • Florida International University (USA)
  • Melbourne University (Australia)
  • Sri Sai Aditya Institute of Pha... (India)
  • University of Ioannina (Greece)
  • More...
Package
Featured Products
L-Leucine

Catalog No: CFN94811
CAS No: 61-90-5
Price: $30/20mg
Kaempferol-7-O-D-glucopyranoside

Catalog No: CFN90150
CAS No: 16290-07-6
Price: $268/5mg
Echinacoside

Catalog No: CFN98105
CAS No: 82854-37-3
Price: $30/20mg
Notoginsenoside T5

Catalog No: CFN92824
CAS No: 769932-34-5
Price: $ / mg
Angelicide

Catalog No: CFN93012
CAS No: 92935-94-9
Price: $ / mg
4-Hydroxybenzaldehyde

Catalog No: CFN99013
CAS No: 123-08-0
Price: $30/20mg
Ginsenoside Rb2

Catalog No: CFN99965
CAS No: 11021-13-9
Price: $100/20mg
Avicularin

Catalog No: CFN98961
CAS No: 572-30-5
Price: $90/20mg
Rhoifolin

Catalog No: CFN99814
CAS No: 17306-46-6
Price: $50/20mg
Licochalcone B

Catalog No: CFN99576
CAS No: 58749-23-8
Price: $268/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: gamma-Fagarine possesses moderate levels of anti-HCV activities with IC₅₀ values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-inducing activity, it induces SCEs in human lymphocyte cultures in a dose-dependent manner. gamma-Fagarine and dictamnine are mutagenic in strain TA100 and TA98 with S9 mix, they have specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there are about 30-50 revertant colonies.
Targets: HCV
In vitro:
Fitoterapia. 2014 Dec;99:276-83.
Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.[Pubmed: 25454460]
Hepatitis C virus (HCV) infection is highly prevalent among global populations, with an estimated number of infected patients being 170 million. Approximately 70-80% of patients acutely infected with HCV will progress to chronic liver disease, such as liver cirrhosis and hepatocellular carcinoma, which is a substantial cause of morbidity and mortality worldwide. New therapies for HCV infection have been developed, however, the therapeutic efficacies still need to be improved. Medicinal plants are promising sources for antivirals against HCV. A variety of plants have been tested and proven to be beneficial as antiviral drug candidates against HCV.
METHODS AND RESULTS:
In this study, we examined extracts, their subfractions and isolated compounds of Ruta angustifolia leaves for antiviral activities against HCV in cell culture. We isolated six compounds, chalepin, scopoletin, γ-fagarine, arborinine, kokusaginine and pseudane IX. Among them, chalepin and pseudane IX showed strong anti-HCV activities with 50% inhibitory concentration (IC₅₀) of 1.7 ± 0.5 and 1.4 ± 0.2 μg/ml, respectively, without apparent cytotoxicity. Their anti-HCV activities were stronger than that of ribavirin (2.8 ± 0.4 μg/ml), which has been widely used for the treatment of HCV infection.
CONCLUSIONS:
Mode-of-action analyses revealed that chalepin and pseudane IX inhibited HCV at the post-entry step and decreased the levels of HCV RNA replication and viral protein synthesis. We also observed that arborinine, kokusaginine and γ-fagarine possessed moderate levels of anti-HCV activities with IC₅₀ values being 6.4 ± 0.7, 6.4 ± 1.6 and 20.4 ± 0.4 μg/ml, respectively, whereas scopoletin did not exert significant anti-HCV activities at 30 μg/ml.
Mutagenesis. 1989 Nov;4(6):467-70.
The SCE-inducing potency of the furoquinoline alkaloid, gamma-fagarine, and a gamma-fagarine-containing tincture from Rutae Herba, in cultured human lymphocytes.[Pubmed: 2695761]

METHODS AND RESULTS:
gamma-Fagarine, a furoquinoline alkaloid naturally occurring in Rutae Herba induces sister chromatid exchanges (SCEs) in human lymphocyte cultures in a dose-dependent manner. The alkaloid is a direct-acting but weak SCE inducer. Similar direct but weak activity was detected in a sample of a commercial Rutae Tinctura which contained 68 micrograms/ml of gamma-Fagarine. The strong toxicity of the tincture makes it difficult to test a broader concentration range.
CONCLUSIONS:
There is some evidence that the SCE-inducing activity of the tincture is mainly due to the presence of gamma-Fagarine.
Mutat Res. 1985 Dec;144(4):221-5.
Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).[Pubmed: 4069140]

METHODS AND RESULTS:
A methanol extract of Dictamni Radicis Cortex exhibited a mutagenic effect on Salmonella typhimurium TA100 and TA98 with S9 mix. Two mutagenic compounds in Dictamni Radicis Cortex were isolated on a Sephadex LH 20 column and silica gel column chromatography and by preparative TLC. These were identified as dictamnine and gamma-Fagarine by UV, EI-Mass, 1H-NMR. Dictamnine and gamma-Fagarine were mutagenic in strain TA100 and TA98 with S9 mix. The dose-response curves were linear in the range 10-40 micrograms.
CONCLUSIONS:
Dictamnine and gamma-Fagarine had specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there were about 30-50 revertant colonies.
gamma-Fagarine Description
Source: The fruits of Zanthoxylum simulans Hance
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Vanillic acid glucoside

Catalog No: CFN95257
CAS No: 32142-31-7
Price: $318/5mg
Methylpicraquassioside B

Catalog No: CFN95379
CAS No: 1443757-89-8
Price: $318/10mg
6-O-(E)-Caffeoylglucopyranose

Catalog No: CFN95105
CAS No: 209797-79-5
Price: $298/5mg
Lucidumol A

Catalog No: CFN95059
CAS No: 217476-73-8
Price: $318/5mg
Selaginellin F

Catalog No: CFN95029
CAS No: 1340493-24-4
Price: $413/5mg
Tigloylgomisin O

Catalog No: CFN95237
CAS No: 130855-74-2
Price: $368/5mg
Arjungenin

Catalog No: CFN95039
CAS No: 58880-25-4
Price: $318/20mg
Senkyunolide N

Catalog No: CFN95449
CAS No: 140694-58-2
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.363 mL 21.815 mL 43.63 mL 87.26 mL 109.075 mL
5 mM 0.8726 mL 4.363 mL 8.726 mL 17.452 mL 21.815 mL
10 mM 0.4363 mL 2.1815 mL 4.363 mL 8.726 mL 10.9075 mL
50 mM 0.0873 mL 0.4363 mL 0.8726 mL 1.7452 mL 2.1815 mL
100 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8726 mL 1.0908 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
L-Leucine

Catalog No: CFN94811
CAS No: 61-90-5
Price: $30/20mg
Kaempferol-7-O-D-glucopyranoside

Catalog No: CFN90150
CAS No: 16290-07-6
Price: $268/5mg
Echinacoside

Catalog No: CFN98105
CAS No: 82854-37-3
Price: $30/20mg
Notoginsenoside T5

Catalog No: CFN92824
CAS No: 769932-34-5
Price: $ / mg
Angelicide

Catalog No: CFN93012
CAS No: 92935-94-9
Price: $ / mg
4-Hydroxybenzaldehyde

Catalog No: CFN99013
CAS No: 123-08-0
Price: $30/20mg
Ginsenoside Rb2

Catalog No: CFN99965
CAS No: 11021-13-9
Price: $100/20mg
Avicularin

Catalog No: CFN98961
CAS No: 572-30-5
Price: $90/20mg
Rhoifolin

Catalog No: CFN99814
CAS No: 17306-46-6
Price: $50/20mg
Licochalcone B

Catalog No: CFN99576
CAS No: 58749-23-8
Price: $268/20mg
Tags: buy gamma-Fagarine | gamma-Fagarine supplier | purchase gamma-Fagarine | gamma-Fagarine cost | gamma-Fagarine manufacturer | order gamma-Fagarine | gamma-Fagarine distributor