Hot Products
| Catalog No. | Information |
| CFN99554 | Icariin Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Icariin has been reported to have anti-hypoxic, phytoestrogenic, anti-osteoporotic, anti-inflammatory, neuroprotective, and anti-depressant-like activities. Icariin is effective in the attenuation of AHR and chronic airway inflammatory changes in OVA-induced murine asthma model, and this effect is associated with regulation of Th17/Treg responses. Icariin inhibited NF-κB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1β axis. |
| CFN96968 | Icariside B1 Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells. |
| CFN96912 | Icariside D2 Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 uM, it induces apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation of AKT in HL-60 cells. |
| CFN99373 | Icariside E5 Icariside E5 may have antioxidant property that strengthen the importance of peppers in the Mediterranean diet. |
| CFN92550 | Icariside I Icariside I is a metabolite product of Icariin. |
| CFN98527 | Icaritin Icaritin, a potent inhibitor of transcription factor SREBPs, which exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, hormone regulation, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. |
| CFN90138 | Ikarisoside F Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level. |
| CFN93149 | Ilexgenin A Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. It has anti-atherosclerotic activity, it shows reduction of atherosclerosis in apolipoprotein E deficient mice. Ilexgenin A is useful in the management of cardiovascular diseases in obesity, it inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner. Ilexgenin A could be regarded as a promising agent for the treatment of melanoma, it exerts anti-melanoma activity by arresting the cell cycle at G0/G1 and regulating IL-6 and TNF-α production. |
| CFN90989 | Ilexhainanoside D Ilexhainanoside D is a natural product from Periploca sepiumBge. |
| CFN90994 | Ilexoside K Ilexoside K is a natural product from Ilex pubescens. |
