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    Natural Products
    Catalog No. Information
    CFN97843 3-O-trans-p-Coumaroyltormentic acid

    1. 3-O-(E)-p-coumaroyl tormentic acid induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, it may be promising lead compound for developing an effective drug for treatment of leukemia.
    2. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively.
    3. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells.
    4. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).
    CFN92194 3-oxo-Olean-12-en-28-oic acid

    1. 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL.
    CFN92805 4,4'-Di-O-methylellagic acid

    1. 4,4'-di-O-methylellagic acid is the most effective compound in the inhibition of colon cancer cell proliferation.
    CFN90723 4',7-Isoflavandiol

    1. 4',7-Isoflavandiol, an estrogen metabolite, affects the ability of soy nuts to improve cardiovascular risk factors.
    2. 4',7-Isoflavandiol may advance breast cancer potential via up-regulation of the eukaryotic initiation factor 4GI (eIF4GI).
    3. 4',7-Isoflavandiol is a potential anticancer agent against HeLa, with possible mechanisms involved in ROS generation and mitochondrial membrane alteration.
    CFN97334 4-Epicommunic acid

    CFN92615 4-Epi-curcumenol

    CFN97575 4'-Hydroxyacetophenone

    1. 4'-Hydroxyacetophenone is a potent xanthine oxidase inhibitor.
    2. Three 4′-hydroxyacetophenone-related phytoalexins from Polymnia sonchifolia, 4′-hydroxy-3′-(3-methylbutanoyl)acetophenone, 4′-hydroxy-3′-(3-methyl-2-butenyl) Acetophenone and 5-acetyl-2-(1-hydroxy-1-methylethyl)benzofuran, have antifungal activity.
    CFN99013 4-Hydroxybenzaldehyde

    1. 4-Hydroxybenzaldehyde shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant.
    CFN97577 4-Hydroxybenzoic acid

    1. 4-Hydroxybenzoic acid derivatives has potential to as pan-HDAC inhibitors with anticancer properties.
    2. 4-Hydroxybenzoic acid positively regulates the expression of gum cluster to promote EPS production in PXO99A.
    3. Some derivatives of 4-Hydroxybenzoic acid are found to possess direct action on Hbs molecules, inhibit acetic acid induced oedema and used in management of sickle cell disease.
    4. 4-Hydroxybenzoic acid and trans 4-hydroxycinnamic acid have anti-bacteria activity against most of the gram-positive and some gram-negative bacteria, at IC50 concentrations of 160 and 100-170 micrograms/ml, respectively.
    CFN97071 4-Hydroxybenzyl alcohol

    1. 4-Hydroxybenzyl alcohol possesses anti-angiogenic, anti-inflammatory and anti- nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines.
    2. 4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.
    3. 4-Hydroxybenzyl alcohol inhibit the development of new blood vessels by targeting multiple mechanisms of the angiogenic process, may as a promising candidate for the establishment of anti-angiogenic treatment strategies in cancer therapy.