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13,18-Dehydroglaucarubinone
13,18-Dehydroglaucarubinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 13,18-Dehydroglaucarubinone
Price:
CAS No.: 68703-94-6
Catalog No.: CFN92980
Molecular Formula: C25H32O10
Molecular Weight: 492.52 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The barks of Ailanthus altissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 13,18-Dehydroglaucarubinone can inhibit growth of the murine lymphocytic leukemia P388.
13,18-Dehydroglaucarubinone Description
Source: The barks of Ailanthus altissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0304 mL 10.1519 mL 20.3037 mL 40.6075 mL 50.7594 mL
5 mM 0.4061 mL 2.0304 mL 4.0607 mL 8.1215 mL 10.1519 mL
10 mM 0.203 mL 1.0152 mL 2.0304 mL 4.0607 mL 5.0759 mL
50 mM 0.0406 mL 0.203 mL 0.4061 mL 0.8121 mL 1.0152 mL
100 mM 0.0203 mL 0.1015 mL 0.203 mL 0.4061 mL 0.5076 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Experientia. 1978 Sep 15;34(9):1122-3.
The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara.[Pubmed: 720499]

METHODS AND RESULTS:
An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2'-acetylglaucarubine (1a) and 13,18-Dehydroglaucarubinone (2). The previously known 2'-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained.
CONCLUSIONS:
The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.
CFN9298013,18-Dehydroglaucarubinone68703-94-6492.52C25H32O10
CFN92979(+)-Glaucarubinone1259-86-5494.53C25H34O10
CFN89335Bruceine B25514-29-8480.46C23H28O11
CFN91974Bruceine C25514-30-1564.58C28H36O12
CFN89336Bruceantinol53729-52-5606.62C30H38O13
CFN95216Bruceantinol B1822332-33-1550.6C27H34O12
CFN91971Bruceantinol A948038-36-6592.59C29H36O13
CFN91973Bruceine J948038-38-8508.51C25H32O11
CFN89338Bruceine A25514-31-2522.54C26H34O11
CFN93119Brusatol14907-98-3520.53C26H32O11
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