2-Deacetoxytaxinine J | CAS:119347-14-7

2-Deacetoxytaxinine J

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Description:

2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.

In vitro:

Eur J Med Chem. 2009 Oct;44(10):3947-53.

In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity.[Pubmed: 19446930]

METHODS AND RESULTS:
The taxane diterpneoid 2-Deacetoxytaxinine J (2-DAT-J) 1 has been isolated from the bark of Himalayan yew, Taxus baccata L. spp. wallichiana in a reasonably good yield (0.1%) and its anticancer activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal human kidney epithelial cell line (HEK-293) has been studied. 2-DAT-J (1) showed significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively. Few novel taxoids were derived (7, 8 and 10-13) from the naturally occurring 2-DAT-J (1) and screened for their anticancer activity.
CONCLUSIONS:
The structure-activity relationship studies indicated that the cinnamoyl group on C-5 and acetyl group on C-10 are essential for the anticancer activity. 2-DAT-J (1) was also tested for its in vivo activity on DMBA-induced mammary tumors in virgin female Sprague Dawley rats at a dose of 10mg/kg body weight orally for 30 days and showed significant regression in mammary tumors as compared to vehicle treated group (p<0.05).

2-Deacetoxytaxinine J Description

Source:	The heartwoods of Taxus cuspidata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1510-3.

Studies on chemical constituents in heartwood of Taxus cuspidata.[Pubmed: 17144468]

To study the chemical constituents in the heartwood of Taxus cuspidata.
METHODS AND RESULTS:
Silica gel column chromatography, preparative HPLC and preparative TLC were used to isolate and purify the chemical constituents; 1H- and 13C-NMR spectroscopic methods were used for structural identification. Ten compounds, taxinine (1), taxusin (2), beta-sitosterol (3), 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl) butanoyloxy-4 (20), 11-taxadiene (5), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxyl-4 (20), 11-taxadiene (yunnanxane) (6), 9alpha, 10beta, 13alpha-triacetoxy-5alpha-cinnamoyltaxa-4 (20), 11-diene (7), 2-Deacetoxytaxinine J (8), taxezopidine G (9), 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyl-taxa-4 (20), 11-dien-5-ol (5-decinnamoyltaxinine J) (10), were isolated and identified from the heartwood of T. cuspidata.
CONCLUSIONS:
Three taxanes, 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxy)-4 (20), 11-taxadiene (yunnanxane) (6), and 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyltaxa-4 (20) , 11-dien-5-ol (10), were obtained from this plant for the first time.

Product Name	2-Deacetoxytaxinine J
Price:	$318 / 10mg
CAS No.:	119347-14-7
Catalog No.:	CFN96989
Molecular Formula:	C₃₇H₄₆O₁₀
Molecular Weight:	650.76 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The heartwoods of Taxus cuspidata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5367 mL	7.6833 mL	15.3666 mL	30.7333 mL	38.4166 mL
5 mM	0.3073 mL	1.5367 mL	3.0733 mL	6.1467 mL	7.6833 mL
10 mM	0.1537 mL	0.7683 mL	1.5367 mL	3.0733 mL	3.8417 mL
50 mM	0.0307 mL	0.1537 mL	0.3073 mL	0.6147 mL	0.7683 mL
100 mM	0.0154 mL	0.0768 mL	0.1537 mL	0.3073 mL	0.3842 mL

CFN96632	Taxumairol B	142203-64-3	568.61	C₂₈H₄₀O₁₂
CFN96412	Yunnanxane	139713-81-8	562.6	C₃₁H₄₆O₉
CFN89037	10-Deacetylyunnanxane	1333323-17-3	520.66	C₂₉H₄₄O₈
CFN96913	2-Deacetoxydecinnamoyltaxinine J	87193-98-4	520.61	C₂₈H₄₀O₉
CFN96905	Decinnamoyltaxinine J	84652-33-5	578.65	C₃₀H₄₂O₁₁
CFN99887	2-Deacetoxytaxinine B	191547-12-3	606.7	C₃₅H₄₂O₉
CFN99855	Taxinine B	18457-44-8	664.8	C₃₇H₄₄O₁₁
CFN96914	7beta-Acetoxytaxuspine C	256347-91-8	664.74	C₃₇H₄₄O₁₁
CFN96639	Taxezopidine G	205440-22-8	608.72	C₃₅H₄₄O₉
CFN89400	7-Deacetoxytaxinine J	18457-45-9	650.75	C₃₇H₄₆O₁₀