2beta-Acetoxyferruginol | CAS:1206461-56-4

2beta-Acetoxyferruginol

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Description:

2beta-Acetoxyferruginol showed activity against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 ug/ml.

Targets:

Antifection

In vitro:

Phytochemistry Letters, 2008, 1(1):49-53.

2β-Acetoxyferruginol—A new antibacterial abietane diterpene from the bark of Prumnopitys andina[Reference: WebLink]

As part of an on-going project to isolate antibacterial compounds from rare conifer species, a new abietane diterpene, 2beta-Acetoxyferruginol was isolated from the stem bark of Prumnopitys andina.
METHODS AND RESULTS:
Molecular modelling studies were conducted to explain some of the NOEs observed in the A-ring of this compound and to support assignment of relative stereochemistry. This new compound had antibacterial activity at 8 μg/ml against two effluxing strains of Staphylococcus aureus, but interestingly was inactive at 128 μg/ml against a wild-type strain and against a methicillin-resistant (MRSA) clinical isolate. We have previously demonstrated that ferruginol is active against these four S. aureus stains and therefore the results indicate that the presence of the acetoxy group has a detrimental effect on antibacterial activity against certain strains. 2beta-Acetoxyferruginol was also assayed against Propionibacterium acnes and was active at 4 μg/ml.Graphical abstractA new antibacterial abietane diterpene, 2beta-Acetoxyferruginol (1) was isolated from the stem bark of Prumnopitys andina and its structure was determined by spectral means.
CONCLUSIONS:
Activity was assessed against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 μg/ml.

2beta-Acetoxyferruginol Description

Source:	The herbs of Salvia yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	2beta-Acetoxyferruginol
Price:
CAS No.:	1206461-56-4
Catalog No.:	CFN92978
Molecular Formula:	C₂₂H₃₂O₃
Molecular Weight:	344.49 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Salvia yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9028 mL	14.5142 mL	29.0284 mL	58.0568 mL	72.571 mL
5 mM	0.5806 mL	2.9028 mL	5.8057 mL	11.6114 mL	14.5142 mL
10 mM	0.2903 mL	1.4514 mL	2.9028 mL	5.8057 mL	7.2571 mL
50 mM	0.0581 mL	0.2903 mL	0.5806 mL	1.1611 mL	1.4514 mL
100 mM	0.029 mL	0.1451 mL	0.2903 mL	0.5806 mL	0.7257 mL

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