3-Hydroxybakuchiol | CAS:178765-54-3 | Manufacturer ChemFaces

3-Hydroxybakuchiol

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Description:

3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation.3-Hydroxybakuchiol has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.

Targets:

Caspase | ATP

In vitro:

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):356-64.

Tumor cell death induced by the inhibition of mitochondrial electron transport: the effect of 3-hydroxybakuchiol.[Pubmed: 23777606]

Changes in mitochondrial ATP synthesis can affect the function of tumor cells due to the dependence of the first step of glycolysis on mitochondrial ATP. The oxidative phosphorylation (OXPHOS) system is responsible for the synthesis of approximately 90% of the ATP in normal cells and up to 50% in most glycolytic cancers; therefore, inhibition of the electron transport chain (ETC) emerges as an attractive therapeutic target.
METHODS AND RESULTS:
We studied the effect of a lipophilic isoprenylated catechol, 3-Hydroxybakuchiol (3-OHbk), a putative ETC inhibitor isolated from Psoralea glandulosa. 3-OHbk exerted cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induced a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation. Additionally, 3-OHbk inhibited oxygen consumption, an effect that was completely reversed by succinate (an electron donor for Complex II) and duroquinol (electron donor for Complex III), suggesting that 3-OHbk disrupted the electron flow at the level of Complex I. The inhibition of OXPHOS did not increase the level of reactive oxygen species (ROS) but caused a large decrease in the intracellular ATP level. ETC inhibitors have been shown to induce cell death through necrosis and apoptosis by increasing ROS generation. Nevertheless, we demonstrated that 3-OHbk inhibited the ETC and induced apoptosis through an interaction with Complex I. By delivering electrons directly to Complex III with duroquinol, cell death was almost completely abrogated.
CONCLUSIONS:
These results suggest that 3-OHbk has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.

3-Hydroxybakuchiol Description

Source:	The herbs of Psoralea corylifolia Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3-Hydroxybakuchiol
Price:	$368 / 10mg
CAS No.:	178765-54-3
Catalog No.:	CFN92703
Molecular Formula:	C₁₈H₂₄O₂
Molecular Weight:	272.4 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The herbs of Psoralea corylifolia Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antioxidants Compound Library Inhibitors Compound Library Antifungal Compound Library Phenols Compound Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6711 mL	18.3554 mL	36.7107 mL	73.4214 mL	91.7768 mL
5 mM	0.7342 mL	3.6711 mL	7.3421 mL	14.6843 mL	18.3554 mL
10 mM	0.3671 mL	1.8355 mL	3.6711 mL	7.3421 mL	9.1777 mL
50 mM	0.0734 mL	0.3671 mL	0.7342 mL	1.4684 mL	1.8355 mL
100 mM	0.0367 mL	0.1836 mL	0.3671 mL	0.7342 mL	0.9178 mL

CFN92702	12-Hydroxyisobakuchiol	178765-55-4	272.4	C₁₈H₂₄O₂
CFN92803	Delta3,2-Hydroxylbakuchiol	178765-49-6	272.4	C₁₈H₂₄O₂
CFN99047	Bakuchiol	10309-37-2	256.4	C₁₈H₂₄O
CFN92703	3-Hydroxybakuchiol	178765-54-3	272.4	C₁₈H₂₄O₂
CFN92704	Psoracorylifol A	879290-97-8	288.4	C₁₈H₂₄O₃
CFN92804	Psoracorylifol C	879290-99-0	288.4	C₁₈H₂₄O₃