3'-Methylflavokawin | CAS:1044743-35-2

3'-Methylflavokawin

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Description:

3'-Methylflavokawin shows cytotoxicity against HeLa cells, the IC 50 value comparable to xanthohumol (8.2-19.2 microM).

In vitro:

J Nat Prod. 2008 Jul;71(7):1237-41.

Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus.[Pubmed: 18611049]

METHODS AND RESULTS:
The minor hop ( Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-Methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. Cytotoxicity was investigated in HeLa cells, and these compounds all had IC 50 values comparable to xanthohumol (8.2-19.2 microM).
CONCLUSIONS:
The ORAC-fluorescein assay revealed potent antioxidative activity for 7 and 8 with 5.2 and 4.8 Trolox equivalents, respectively.

3'-Methylflavokawin Description

Source:	The herbs of Humulus lupulus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3'-Methylflavokawin
Price:
CAS No.:	1044743-35-2
Catalog No.:	CFN96084
Molecular Formula:	C₁₈H₁₈O₅
Molecular Weight:	314.3 g/mol
Purity:	>=98%
Type of Compound:	Chalcones
Physical Desc.:	Yellow powder
Source:	The herbs of Humulus lupulus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Chalcones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1817 mL	15.9084 mL	31.8167 mL	63.6335 mL	79.5418 mL
5 mM	0.6363 mL	3.1817 mL	6.3633 mL	12.7267 mL	15.9084 mL
10 mM	0.3182 mL	1.5908 mL	3.1817 mL	6.3633 mL	7.9542 mL
50 mM	0.0636 mL	0.3182 mL	0.6363 mL	1.2727 mL	1.5908 mL
100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.6363 mL	0.7954 mL

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CFN89427	4,2'-Dihydroxy-4'-methoxychalcone	63529-06-6	270.28	C₁₆H₁₄O₄
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CFN70345	2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone	35241-54-4	302.3	C₁₇H₁₈O₅
CFN91680	2'-O-Methylphloretin (4,2',4'-Trihydroxy-6'-methoxydihydrochalcone)	111316-17-7	288.3	C₁₆H₁₆O₅
CFN97065	Helichrysetin	62014-87-3	286.3	C₁₆H₁₄O₅
CFN97962	2,4-Dihydroxy-4,6-dimethoxydihydrochalcone	75679-58-2	302.3	C₁₇H₁₈O₅
CFN70304	2',6'-Dihydroxy-4,4'-dimethoxychalcone	20621-49-2	300.3	C₁₇H₁₆O₅