4'-O-Methylbroussochalcone B | CAS:20784-60-5

4'-O-Methylbroussochalcone B

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Product Name	4'-O-Methylbroussochalcone B
Price:	$198 / 20mg
CAS No.:	20784-60-5
Catalog No.:	CFN98046
Molecular Formula:	C₂₁H₂₂O₄
Molecular Weight:	338.4 g/mol
Purity:	>=98%
Type of Compound:	Chalcones
Physical Desc.:	Yellow powder
Source:	The seeds of Psoralea corylifolia Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $42.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Reference standards.

In vitro:

Journal of Natural Products,2018, 81(4):966-975.

Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.[Pubmed: 29641206]

Postmenopausal women are increasingly using botanicals for menopausal symptom relief due to the increased breast cancer risk associated with traditional estrogen therapy. The deleterious effects of estrogens are associated with estrogen receptor (ER)α-dependent proliferation, while ERβ activation could enhance safety by opposing ERα effects.
METHODS AND RESULTS:
Three medicinal licorice species, Glycyrrhiza glabra ( G. glabra), G. uralensis, and G. inflata, were studied for their differential estrogenic efficacy. The data showed higher estrogenic potency for G. inflata in an alkaline phosphatase induction assay in Ishikawa cells (ERα) and an estrogen responsive element (ERE)-luciferase assay in MDA-MB-231/β41 breast cancer cells (ERβ). Bioassay-guided fractionation of G. inflata led to the isolation of 8-prenylapigenin (3). Surprisingly, a commercial batch of 3 was devoid of estrogenic activity. Quality control by MS and qNMR revealed an incorrect compound, 4'- O-methylbroussochalcone B (10), illustrating the importance of both structural and purity verification prior to any biological investigations. Authentic and pure 3 displayed 14-fold preferential ERβ agonist activity. Quantitative analyses revealed that 3 was 33 times more concentrated in G. inflata compared to the other medicinal licorice extracts.
CONCLUSIONS:
These data suggest that standardization of G. inflata to 3 might enhance the safety and efficacy of G. inflata supplements used for postmenopausal women's health.

4'-O-Methylbroussochalcone B Description

Source:	The seeds of Psoralea corylifolia Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Chalcones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	59.1017 mL	73.8771 mL
5 mM	0.591 mL	2.9551 mL	5.9102 mL	11.8203 mL	14.7754 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	5.9102 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.591 mL	1.182 mL	1.4775 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.591 mL	0.7388 mL

CFN92221	Bavachalcone	28448-85-3	324.4	C₂₀H₂₀O₄
CFN98046	4'-O-Methylbroussochalcone B	20784-60-5	338.4	C₂₁H₂₂O₄
CFN98593	Isobavachalcone	20784-50-3	324.37	C₂₀H₂₀O₄
CFN92015	Desmethylxanthohumol	115063-39-3	340.4	C₂₀H₂₀O₅
CFN98958	Xanthohumol	569-83-5; 6754-58-1	354.4	C₂₁H₂₂O₅
CFN98328	Xanthohumol D	274675-25-1	370.4	C₂₁H₂₂O₆
CFN92227	Corylifol B	775351-90-1	340.4	C₂₀H₂₀O₅
CFN97241	Morachalcone A	76472-88-3	340.4	C₂₀H₂₀O₅
CFN92006	Kuraridine	34981-25-4	438.5	C₂₆H₃₀O₆