9-Hydroxycalabaxanthone hydrate | CAS:N/A

9-Hydroxycalabaxanthone hydrate

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Description:

The combination of 9-hydroxycalabaxanthone with α-mangostin showed the synergistic antimalarial interaction in both clones.

In vitro:

Acta Parasitologica, 2014, 60(1).

The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with mefloquine/artesunate.[Reference: WebLink]

Multidrug resistance Plasmodium falciparum is the major health problem in Thailand. Discovery and development of new antimalarial drugs with novel modes of action is urgently required.
METHODS AND RESULTS:
The aim of the present study was to investigate the antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with the standard antimalarial drugs mefloquine and artesunate in chloroquine sensitive (3D7) and chloroquine resistant (K1) P. falciparum clones in vitro. Median (range) IC50 (drug concentration which produces 50% parasite growth inhibition) values of the 9-hydroxycalabaxanthone, α-mangostin, artesunate and mefloquine for 3D7 vs K1 clones were 1.5 (0.9-2.1) vs 1.2 (1.1-1.6) μM, 17.9 (15.7.0-20.0) vs 9.7 (6.0-14.0) μM, 1.0 (0.4-3.0) vs 1.7 (1.0-2.5) nM, and 13.3 (11.1-13.3) vs 7.1 (6.7-12.2) nM, respectively. Analysis of isobologram and combination index (CI) of 9-hydroxycalabaxanthone with artesunate or mefloquine showed synergistic and indifference antimalarial interaction, respectively. α-mangostin-artesunate combination exhibited a slight antagonistic effect of antimalarial interaction, whereas α-mangostin and mefloquine combination showed indifference interaction in both clones.
CONCLUSIONS:
The combination of 9-hydroxycalabaxanthone with α-mangostin showed the synergistic antimalarial interaction in both clones.

9-Hydroxycalabaxanthone hydrate Description

Source:	The fruits of Garcinia mangostana.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	9-Hydroxycalabaxanthone hydrate
Price:
CAS No.:	N/A
Catalog No.:	CFN97580
Molecular Formula:	C₂₄H₂₆O₇
Molecular Weight:	426.5 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Yellow powder
Source:	The fruits of Garcinia mangostana.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Xanthones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3447 mL	11.7233 mL	23.4467 mL	46.8933 mL	58.6166 mL
5 mM	0.4689 mL	2.3447 mL	4.6893 mL	9.3787 mL	11.7233 mL
10 mM	0.2345 mL	1.1723 mL	2.3447 mL	4.6893 mL	5.8617 mL
50 mM	0.0469 mL	0.2345 mL	0.4689 mL	0.9379 mL	1.1723 mL
100 mM	0.0234 mL	0.1172 mL	0.2345 mL	0.4689 mL	0.5862 mL

CFN95114	1-Isomangostin	19275-44-6	410.5	C₂₄H₂₆O₆
CFN91523	11-hydroxy-1-isomangostin	164365-71-3	426.5	C₂₄H₂₆O₇
CFN98294	1-Isomangostin hydrate	26063-95-6	428.5	C₂₄H₂₈O₇
CFN99645	Isonormangostin	15404-80-5	396.4	C₂₃H₂₄O₆
CFN97580	9-Hydroxycalabaxanthone hydrate	N/A	426.5	C₂₄H₂₆O₇
CFN98295	3-Isomangostin hydrate	26063-96-7	428.5	C₂₄H₂₈O₇
CFN97490	3-Isomangostin hydrate formate	925705-36-8	456.5	C₂₅H₂₈O₈
CFN91408	7-(3-Acetoxy-3-methyl-butyl)-5,9-dihydroxy-8-methoxy-2,2-dimethyl-3,4-dihydro-2H-pyrano[3,2-b]xanthen-6-one	26063-98-9	470.5	C₂₆H₃₀O₈
CFN98467	9-Hydroxycalabaxanthone	35349-68-9	408.5	C₂₄H₂₄O₆
CFN99724	3-Isomangostin	19275-46-8	410.46	C₂₄H₂₆O₆