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Aflavazole
Aflavazole
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Aflavazole
Price:
CAS No.: 2043963-70-6
Catalog No.: CFN89038
Molecular Formula: C28H35NO2
Molecular Weight: 417.59 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The metabolites of the sclerotia of Aspergillus flavus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Aflavazole displays significant antifeedant activity against the fungivorous beetle Carpophilus hemipterus.
In vitro:
Journal of Organic Chemistry, 1990, 55(18):5299-5301.
Aflavazole: A new antiinsectan carbazole metabolite from the sclerotia of Aspergillus flavus.[Reference: WebLink]

METHODS AND RESULTS:
The isolation, structure elucidation and biological activity of Aflavazole, a carbazole metabolite from the sclerotia of A. flavus, are reported.
CONCLUSIONS:
Aflavazole displayed significant antifeedant activity against the fungivorous beetle Carpophilus hemipterus when incorporated into a standard test diet at 100 p.p.m.
Aflavazole Description
Source: The metabolites of the sclerotia of Aspergillus flavus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3947 mL 11.9735 mL 23.9469 mL 47.8939 mL 59.8673 mL
5 mM 0.4789 mL 2.3947 mL 4.7894 mL 9.5788 mL 11.9735 mL
10 mM 0.2395 mL 1.1973 mL 2.3947 mL 4.7894 mL 5.9867 mL
50 mM 0.0479 mL 0.2395 mL 0.4789 mL 0.9579 mL 1.1973 mL
100 mM 0.0239 mL 0.1197 mL 0.2395 mL 0.4789 mL 0.5987 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Am Chem Soc. 2016 Dec 7;138(48):15555-15558.
Total Syntheses of Aflavazole and 14-Hydroxyaflavinine.[Pubmed: 27934032 ]
The first total syntheses of Aflavazole (6) and 14-hydroxyaflavinine (8), two sterically congested indole diterpenoids, were accomplished. AlI3-promoted alkyne Prins cyclization was exploited to construct their key structural motifs. An electrocyclization-aromatization sequence assembled the pentasubstituted arene of 6, and a Stille-Migita coupling furnished the tetrasubstituted olefin of 8. The benzylic and allylic C-O bonds were reductively cleaved at the late stage of the syntheses, respectively.
CFN70408Syringetin 3-O-galactoside55025-56-4508.4C23H24O13
CFN95180Isonardosinone27062-01-7264.3C15H20O4
CFN90582(-)-Isocorypalmine483-34-1341.4C20H23NO4
CFN89223Rutamarin14882-94-1356.41C21H24O5
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