Alloalantolactone | CAS:64340-41-6 | Manufacturer ChemFaces

Alloalantolactone

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Size /Price /Stock	10 mM * 1 mL in DMSO / $144.7 / In-stock
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Description:

Alloalantolactone shows activity against M. tuberculosis (32 micrograms/ml).

Targets:

Antifection

In vitro:

Planta Med. 1999 May;65(4):351-5.

Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.[Pubmed: 10364842]

In a bioassay guided search for antimycobacterial compounds from higher plants, the root extracts of Elecampane (Inula helenium L.; Asteraceae) and Sweet Coneflower (Rudbeckia subtomentosa Pursh.; Asteraceae) were chemically investigated for their active constituents.
METHODS AND RESULTS:
Chromatographic fractions of root extracts of l. helenium, which exhibited significant activity against Mycobacterium tuberculosis, provided the known eudesmanolides alantolactone, isoalantolactone, and 11 alpha H, 13-dihydroisoalantolactone. Peracid epoxidation of alantolactone and isoalantolactone provided 5 alpha-epoxyalantolactone and 4(15) alpha-epoxyisoalantolactone, respectively and oxidation of alantolactone with OsO4 gave 11,13-dihydroxyalantolactone. Active fractions from R subtomentosa contained the known Alloalantolactone and 3-oxoAlloalantolactone. The structures of the above compounds were established by spectroscopic methods including 1D and 2D NMR techniques as well as spectral comparison with previously reported data. The molecular structure of 5 alpha-epoxyalantolactone was determined by single crystal X-ray diffraction. Eleven natural and semisynthetic eudesmanolides were tested in a radiorespirometric bioassay for activity against M. tuberculosis. 5 alpha-Epoxyalantolactone and encelin from Montanoa speciosa showed minimum inhibitory concentrations (MICs) of 8 and 16 micrograms ml-1, respectively. Alantolactone, isoalantolactone and its 4 alpha, 15-epoxide, 1,2-dehydro-3-epi-isotelekin and Alloalantolactone gave MICs of 32 micrograms ml-1.
CONCLUSIONS:
All other compounds showed MIC values of 128 micrograms ml-1 or higher.

Alloalantolactone Description

Source:	The roots of Inula helenium
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Alloalantolactone
Price:	$318 / 10mg
CAS No.:	64340-41-6
Catalog No.:	CFN91880
Molecular Formula:	C₁₅H₂₀O₂
Molecular Weight:	232.32 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The roots of Inula helenium
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3044 mL	21.522 mL	43.0441 mL	86.0882 mL	107.6102 mL
5 mM	0.8609 mL	4.3044 mL	8.6088 mL	17.2176 mL	21.522 mL
10 mM	0.4304 mL	2.1522 mL	4.3044 mL	8.6088 mL	10.761 mL
50 mM	0.0861 mL	0.4304 mL	0.8609 mL	1.7218 mL	2.1522 mL
100 mM	0.043 mL	0.2152 mL	0.4304 mL	0.8609 mL	1.0761 mL

CFN91880	Alloalantolactone	64340-41-6	232.32	C₁₅H₂₀O₂
CFN92599	Ivangustin	14164-59-1	248.3	C₁₅H₂₀O₃
CFN99934	Alantolactone	546-43-0	232.32	C₁₅H₂₀O₂
CFN92600	1beta-Hydroxyalantolactone	68776-47-6	248.3	C₁₅H₂₀O₃
CFN98107	Isoalantolactone	470-17-7	232.32	C₁₆H₂₀O₂
CFN97819	11,13-Dihydroivalin	150150-61-1	250.34	C₁₅H₂₂O₃