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Alstoyunine E
Alstoyunine E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Alstoyunine E
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CAS No.: 1188932-15-1
Catalog No.: CFN97910
Molecular Formula: C21H22N2O3
Molecular Weight: 350.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Alstonia yunnanensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Alstoyunine E shows selective inhibition of Cox-2 (>75%).
Targets: COX
In vitro:
J Nat Prod. 2009 Oct;72(10):1836-41.
Monoterpenoid indole alkaloids from Alstonia yunnanensis.[Pubmed: 19775092]
Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis.
METHODS AND RESULTS:
The structures of the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunine C (3), Alstoyunine E (5), and Alstoyunine F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC50 = 3.89 microM) and hepatocellular carcinoma SMMC-7721 (IC50 = 21.73 microM) cell lines.
Alstoyunine E Description
Source: The herbs of Alstonia yunnanensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8539 mL 14.2694 mL 28.5388 mL 57.0776 mL 71.347 mL
5 mM 0.5708 mL 2.8539 mL 5.7078 mL 11.4155 mL 14.2694 mL
10 mM 0.2854 mL 1.4269 mL 2.8539 mL 5.7078 mL 7.1347 mL
50 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.1416 mL 1.4269 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.5708 mL 0.7135 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN92503Ajmalimine59846-31-0520.6C30H36N2O6
CFN92504Rauvomitin466-57-9502.6C30H34N2O5
CFN96749Rauvotetraphylline D1422506-52-2390.48C24H26N2O3
CFN97757Vinorine34020-07-0334.42C21H22N2O2
CFN97910Alstoyunine E1188932-15-1350.4C21H22N2O3
CFN97762Raucaffricine31282-07-2512.56C27H32N2O8
CFN98673Perakine4382-56-3350.4 C21H22N2O3
CFN92509(+)-Isoajmaline6989-79-3326.4C20H26N2O2
CFN93513Ajmaline4360-12-7326.4C20H26N2O2
CFN92581Ajmalidine639-30-5324.4C20H24N2O2
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