Aphagranin A | CAS:1318173-53-3 | Manufacturer ChemFaces

Aphagranin A

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Description:

Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.

In vitro:

Tetrahedron Letters, 2012, 53(14):1705-9.

A pair of tirucallane C27-triterpenoid cyclopentenone epimers from the stem barks of Aphanamixis grandifolia[Reference: WebLink]

METHODS AND RESULTS:
Two novel tirucallane C27-triterpenoid epimers, aphagranins A (1) and B (2), featuring an unprecedented enolized cyclopentenone presented in the side-chain at C-17, were isolated from the stem barks of Aphanamixis grandifolia. Extensive spectroscopic analyses helped the establishment of the structures of the two isolates, whose absolute configurations were determined using density functional theory (DFT) calculations of optical rotation, and electronic circular dichroism (ECD).
CONCLUSIONS:
Remarkable discrepancies in the inhibitory activities against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823) were found for the two epimers: with IC50 less than 10 μM, Aphagranin A exhibited much stronger antiproliferative activity than aphagranin B, showing no such activities with IC50 over 20 μM.

Aphagranin A Description

Source:	The stem barks of Aphanamixis grandifolia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Aphagranin A
Price:
CAS No.:	1318173-53-3
Catalog No.:	CFN96579
Molecular Formula:	C₃₃H₅₄O₆
Molecular Weight:	546.79 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The stem barks of Aphanamixis grandifolia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8289 mL	9.1443 mL	18.2886 mL	36.5771 mL	45.7214 mL
5 mM	0.3658 mL	1.8289 mL	3.6577 mL	7.3154 mL	9.1443 mL
10 mM	0.1829 mL	0.9144 mL	1.8289 mL	3.6577 mL	4.5721 mL
50 mM	0.0366 mL	0.1829 mL	0.3658 mL	0.7315 mL	0.9144 mL
100 mM	0.0183 mL	0.0914 mL	0.1829 mL	0.3658 mL	0.4572 mL

CFN90803	16 alpha-Hydroxytrametenolic acid	176390-68-4	472.7	C₃₀H₄₈O₄
CFN90804	3-O-Acetyl-16 alpha-hydroxytrametenolic acid	168293-13-8	514.8	C₃₂H₅₀O₅
CFN90577	Dehydrotrametenolic acid	29220-16-4	454.69	C₃₀H₄₆O₃
CFN90790	16alpha-Hydroxydehydrotrametenolic acid	176390-66-2	470.7	C₃₀H₄₆O₄
CFN90791	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	168293-14-9	512.7	C₃₂H₄₈O₅
CFN95050	Poricoic acid B	137551-39-4	484.7	C₃₀H₄₄O₅
CFN95056	Poricoic acid G	415724-84-4	486.7	C₃₀H₄₆O₅
CFN89516	Euphol	514-47-6	426.71	C₃₀H₅₀O
CFN91600	Euphorbol	566-14-3	440.7	C₃₁H₅₂O
CFN92368	Lanosterol	79-63-0	426.7	C₃₀H₅₀O